2-(3-Fluoro-phenyl)-cyclopropanecarboxylic acid

Base Information

• Chemical Name: 2-(3-Fluoro-phenyl)-cyclopropanecarboxylic acid
• CAS No.: 1157561-41-5
• Molecular Formula: C₁₀H₉FO₂
• Molecular Weight: 180.179
• Mol file: 1157561-41-5.mol

Synonyms:

Chemical Property of 2-(3-Fluoro-phenyl)-cyclopropanecarboxylic acid

Chemical Property:

• Boiling Point: 309.9±42.0 °C(Predicted)
• PKA: 4.54±0.10(Predicted)
• Density: 1.345±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-(3-Fluorophenyl)cyclopropane-1-carboxylic acid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-(3-Fluorophenyl)cyclopropanecarboxylic acid is used as a reactant in the preparation of N-acyl-4-(heterocyclylaminomethyl)piperidines as NMDA/NR2B antagonists.

Technology Process of 2-(3-Fluoro-phenyl)-cyclopropanecarboxylic acid

There total 23 articles about 2-(3-Fluoro-phenyl)-cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

Methyl 2-(3-fluorophenyl)cyclopropanecarboxylate → 2-(3-fluorophenyl)cyclopropanecarboxylic acid (1157561-41-5)

Guidance literature:

Methyl 2-(3-fluorophenyl)cyclopropanecarboxylate; With methanol; sodium hydroxide; at 20 ℃;

With hydrogenchloride; In water;

Reference yield: 98.0%

N-methoxy-N-methyl-trans-2-(3-fluorophenyl)cyclopropanecarboxamide → rac-trans-2-(3-fluorophenyl)-cyclopropanecarboxylic acid (1157561-41-5)

Guidance literature:

With potassium tert-butylate; In diethyl ether; at 20 ℃; for 16h;

DOI:10.1139/cjc-77-5-6-1123

Reference yield: 85.0%

rac-trans-2-(3-fluorophenyl)-cyclopropanecarboxylic acid ethyl ester → rac-trans-2-(3-fluorophenyl)-cyclopropanecarboxylic acid (1157561-41-5)

Guidance literature:

With potassium hydroxide; In methanol; at 0 - 20 ℃; for 18h;

upstream raw materials:

3-Fluorocinnamic acid

methyl (E)-m-fluorocinnamate

(2E)-3-(3-fluorophenyl)-N-methoxy-N-methylmethylacrylamide

3-Fluorobenzaldehyde

Downstream raw materials:

(1S,2S)-2-(3-fluorophenyl)-cyclopropanecarboxylic acid

C₃₇H₅₅FN₄O₇

(1S,2R)-2-(3-fluorophenyl)cyclopropanamine

(1R,2S)-2-(3-fluorophenyl)cyclopropanamine