3,6-di((S)-sec-butyl)-3-hydroxy-1-methoxy-4-(2-methoxyphenoxy)piperazine-2,5-dione

Base Information

Chemical Name:3,6-di((S)-sec-butyl)-3-hydroxy-1-methoxy-4-(2-methoxyphenoxy)piperazine-2,5-dione
CAS No.:1264728-52-0
Molecular Formula:C₂₀H₃₀N₂O₆
Molecular Weight:394.468
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3,6-di((S)-sec-butyl)-3-hydroxy-1-methoxy-4-(2-methoxyphenoxy)piperazine-2,5-dione

Chemical Property:

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Technology Process of 3,6-di((S)-sec-butyl)-3-hydroxy-1-methoxy-4-(2-methoxyphenoxy)piperazine-2,5-dione

There total 11 articles about 3,6-di((S)-sec-butyl)-3-hydroxy-1-methoxy-4-(2-methoxyphenoxy)piperazine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: bis(2-methoxyphenyl)iodonium tetrafluoroborate salt

: 1264728-36-0
3,6-di((S)-sec-butyl)-3,4-dihydroxy-1-methoxypiperazine-2,5-dione

: 1264728-52-0
3,6-di((S)-sec-butyl)-3-hydroxy-1-methoxy-4-(2-methoxyphenoxy)piperazine-2,5-dione

Guidance literature:: With copper acetylacetonate; potassium carbonate; In water; toluene; at 20 ℃; for 2.5h; Inert atmosphere;
DOI:10.1021/jo102228j

Reference yield:

: 73-32-5,959215-79-3,18875-42-8
L-isoleucine

: 1264728-52-0
3,6-di((S)-sec-butyl)-3-hydroxy-1-methoxy-4-(2-methoxyphenoxy)piperazine-2,5-dione

Guidance literature:: Multi-step reaction with 7 steps

1: hydrogen bromide; sodium nitrite / water / 4 h / 0 °C / Inert atmosphere

2: thionyl chloride / chloroform / Inert atmosphere; Reflux

3: triethylamine / dichloromethane / 3.12 h / 20 °C / Inert atmosphere

4: 15-crown-5; sodium hydroxide / water; toluene / 2 h / 95 °C

5: 20 % Pd(OH)2/C; hydrogen / tetrahydrofuran / 1.5 h / 20 °C

6: water; manganese triacetate / acetonitrile / 6 h / 20 °C

7: copper acetylacetonate; potassium carbonate / water; toluene / 2.5 h / 20 °C / Inert atmosphere

With copper acetylacetonate; thionyl chloride; 15-crown-5; 20 % Pd(OH)2/C; water; hydrogen bromide; hydrogen; manganese triacetate; potassium carbonate; triethylamine; sodium hydroxide; sodium nitrite; In tetrahydrofuran; dichloromethane; chloroform; water; toluene; acetonitrile;
DOI:10.1021/jo102228j

Reference yield:

: 202067-24-1
C₆H₁₁BrO₂

: 1264728-52-0
3,6-di((S)-sec-butyl)-3-hydroxy-1-methoxy-4-(2-methoxyphenoxy)piperazine-2,5-dione

Guidance literature:: Multi-step reaction with 6 steps

1: thionyl chloride / chloroform / Inert atmosphere; Reflux

2: triethylamine / dichloromethane / 3.12 h / 20 °C / Inert atmosphere

3: 15-crown-5; sodium hydroxide / water; toluene / 2 h / 95 °C

4: 20 % Pd(OH)2/C; hydrogen / tetrahydrofuran / 1.5 h / 20 °C

5: water; manganese triacetate / acetonitrile / 6 h / 20 °C

6: copper acetylacetonate; potassium carbonate / water; toluene / 2.5 h / 20 °C / Inert atmosphere

With copper acetylacetonate; thionyl chloride; 15-crown-5; 20 % Pd(OH)2/C; water; hydrogen; manganese triacetate; potassium carbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane; chloroform; water; toluene; acetonitrile;
DOI:10.1021/jo102228j