((2S,3S,4S,6S)-6-{(2S,3S,4S,6S)-6-[(1S,2R)-1-((S)-1-Benzyloxy-ethyl)-3-(diphenyl-phosphinoyl)-2-methyl-propoxy]-4-methoxy-2-methyl-tetrahydro-pyran-3-yloxy}-4-methoxy-2-methyl-tetrahydro-pyran-3-yloxy)-tert-butyl-dimethyl-silane

Base Information

• Chemical Name: ((2S,3S,4S,6S)-6-{(2S,3S,4S,6S)-6-[(1S,2R)-1-((S)-1-Benzyloxy-ethyl)-3-(diphenyl-phosphinoyl)-2-methyl-propoxy]-4-methoxy-2-methyl-tetrahydro-pyran-3-yloxy}-4-methoxy-2-methyl-tetrahydro-pyran-3-yloxy)-tert-butyl-dimethyl-silane
• CAS No.: 117475-68-0
• Molecular Formula: C₄₅H₆₇O₉PSi
• Molecular Weight: 811.081
• Mol file: 117475-68-0.mol

Synonyms:

Chemical Property of ((2S,3S,4S,6S)-6-{(2S,3S,4S,6S)-6-[(1S,2R)-1-((S)-1-Benzyloxy-ethyl)-3-(diphenyl-phosphinoyl)-2-methyl-propoxy]-4-methoxy-2-methyl-tetrahydro-pyran-3-yloxy}-4-methoxy-2-methyl-tetrahydro-pyran-3-yloxy)-tert-butyl-dimethyl-silane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((2S,3S,4S,6S)-6-{(2S,3S,4S,6S)-6-[(1S,2R)-1-((S)-1-Benzyloxy-ethyl)-3-(diphenyl-phosphinoyl)-2-methyl-propoxy]-4-methoxy-2-methyl-tetrahydro-pyran-3-yloxy}-4-methoxy-2-methyl-tetrahydro-pyran-3-yloxy)-tert-butyl-dimethyl-silane

There total 11 articles about ((2S,3S,4S,6S)-6-{(2S,3S,4S,6S)-6-[(1S,2R)-1-((S)-1-Benzyloxy-ethyl)-3-(diphenyl-phosphinoyl)-2-methyl-propoxy]-4-methoxy-2-methyl-tetrahydro-pyran-3-yloxy}-4-methoxy-2-methyl-tetrahydro-pyran-3-yloxy)-tert-butyl-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Pent-3-yn-2-ol (57984-70-0,58072-60-9,90242-65-2,27301-54-8) → ((2S,3S,4S,6S)-6-{(2S,3S,4S,6S)-6-[(1S,2R)-1-((S)-1-Benzyloxy-ethyl)-3-(diphenyl-phosphinoyl)-2-methyl-propoxy]-4-methoxy-2-methyl-tetrahydro-pyran-3-yloxy}-4-methoxy-2-methyl-tetrahydro-pyran-3-yloxy)-tert-butyl-dimethyl-silane (117475-68-0)

Guidance literature:

Multi-step reaction with 7 steps

1: 2.) 3-chloroperoxybenzoic acid / 1.) Lindlar's catalyst

2: 83 percent / NaH / dimethylformamide / 25 °C

3: 1,2-dimethoxy-ethane / 25 °C

4: toluene / 80 °C

5: NaOEt / ethanol / Heating

7: 1.) phenylselenyl chloride, 2,4,6-collidine; 2.) Ph₃SnH / 1.) CH₃CN, 0-25 deg C; 2.) reflux, PhMe

With 2,4,6-trimethyl-pyridine; Phenylselenyl chloride; triphenylstannane; sodium ethanolate; sodium hydride; 3-chloro-benzenecarboperoxoic acid; Lindlar's catalyst; In 1,2-dimethoxyethane; ethanol; N,N-dimethyl-formamide; toluene;

DOI:10.1016/S0040-4039(00)82065-1

Reference yield:

(2α(S*),3α)-(+/-)-α,3-Dimethyloxiranemethanol (22520-29-2,26091-69-0,34501-27-4,74164-00-4,79702-78-6,79702-79-7,80183-20-6,81871-92-3,117557-30-9,131432-12-7,140696-25-9,143061-82-9,144539-36-6) → ((2S,3S,4S,6S)-6-{(2S,3S,4S,6S)-6-[(1S,2R)-1-((S)-1-Benzyloxy-ethyl)-3-(diphenyl-phosphinoyl)-2-methyl-propoxy]-4-methoxy-2-methyl-tetrahydro-pyran-3-yloxy}-4-methoxy-2-methyl-tetrahydro-pyran-3-yloxy)-tert-butyl-dimethyl-silane (117475-68-0)

Guidance literature:

Multi-step reaction with 6 steps

1: 83 percent / NaH / dimethylformamide / 25 °C

2: 1,2-dimethoxy-ethane / 25 °C

3: toluene / 80 °C

4: NaOEt / ethanol / Heating

6: 1.) phenylselenyl chloride, 2,4,6-collidine; 2.) Ph₃SnH / 1.) CH₃CN, 0-25 deg C; 2.) reflux, PhMe

With 2,4,6-trimethyl-pyridine; Phenylselenyl chloride; triphenylstannane; sodium ethanolate; sodium hydride; In 1,2-dimethoxyethane; ethanol; N,N-dimethyl-formamide; toluene;

DOI:10.1016/S0040-4039(00)82065-1

Reference yield:

(2S,3S)-2-((S)-1-Benzyloxy-ethyl)-3-methyl-oxirane (117452-71-8,140696-27-1) → ((2S,3S,4S,6S)-6-{(2S,3S,4S,6S)-6-[(1S,2R)-1-((S)-1-Benzyloxy-ethyl)-3-(diphenyl-phosphinoyl)-2-methyl-propoxy]-4-methoxy-2-methyl-tetrahydro-pyran-3-yloxy}-4-methoxy-2-methyl-tetrahydro-pyran-3-yloxy)-tert-butyl-dimethyl-silane (117475-68-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 1,2-dimethoxy-ethane / 25 °C

2: toluene / 80 °C

3: NaOEt / ethanol / Heating

5: 1.) phenylselenyl chloride, 2,4,6-collidine; 2.) Ph₃SnH / 1.) CH₃CN, 0-25 deg C; 2.) reflux, PhMe

With 2,4,6-trimethyl-pyridine; Phenylselenyl chloride; triphenylstannane; sodium ethanolate; In 1,2-dimethoxyethane; ethanol; toluene;

DOI:10.1016/S0040-4039(00)82065-1

upstream raw materials:

(2S,3S,4S,6S)-6-[(1S,2R)-1-((S)-1-Benzyloxy-ethyl)-3-(diphenyl-phosphinoyl)-2-methyl-propoxy]-4-methoxy-2-methyl-tetrahydro-pyran-3-ol

Pent-3-yn-2-ol

(2α(S*),3α)-(+/-)-α,3-Dimethyloxiranemethanol

(2S,3S)-2-((S)-1-Benzyloxy-ethyl)-3-methyl-oxirane