trans-(+/-)-3,4,4',5'-Tetrahydro-4'-(4-chlorophenyl)-spiropyrazol>-1-one

Base Information

• Chemical Name: trans-(+/-)-3,4,4',5'-Tetrahydro-4'-(4-chlorophenyl)-spiropyrazol>-1-one
• CAS No.: 138421-83-7
• Molecular Formula: C₁₈H₁₅ClN₂O
• Molecular Weight: 310.783

Synonyms:

Chemical Property of trans-(+/-)-3,4,4',5'-Tetrahydro-4'-(4-chlorophenyl)-spiropyrazol>-1-one

Chemical Property:

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Technology Process of trans-(+/-)-3,4,4',5'-Tetrahydro-4'-(4-chlorophenyl)-spiropyrazol>-1-one

There total 2 articles about trans-(+/-)-3,4,4',5'-Tetrahydro-4'-(4-chlorophenyl)-spiropyrazol>-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.7%

diazomethane (186581-53-3,908094-01-9,334-88-3) + E-2-(4-chlorobenzylidene)-1-tetralone (49545-70-2) → trans-(+/-)-3,4,4',5'-Tetrahydro-4'-(4-chlorophenyl)-spiropyrazol>-1-one (138421-80-4,138421-83-7,145412-03-9,145412-07-3)

Guidance literature:

In diethyl ether; acetone; for 48h; Mechanism; in a refrigerator; other arylidene-1-tetralone;

DOI:10.1002/mrc.1260300308

Reference yield: 77.8%

diazomethane (186581-53-3,908094-01-9,334-88-3) + (Z)-2-(4-Chlorobenzylidene)-1-tetralone (59082-35-8) → cis-(+/-)-3,4,4',5'-Tetrahydro-4'-(4-chlorophenyl)-spiropyrazol>-1-one (138421-80-4,138421-83-7,145412-03-9,145412-07-3)

Guidance literature:

In diethyl ether; acetone; for 48h; in a refrigerator;

DOI:10.1002/mrc.1260300308

Reference yield: 71.1%

trans-(+/-)-3,4,4',5'-Tetrahydro-4'-(4-chlorophenyl)-spiropyrazol>-1-one (138421-80-4,138421-83-7,145412-03-9,145412-07-3) → Z-2-(α-methyl-4-chlorobenzylidene)-1-tetralone (138421-99-5) + E-2-(α-methyl-4-chlorobenzylidene)-1-tetralone (138421-90-6) + cis-2-(4-chlorophenyl-cyclopropyl)-1-tetralone (138422-07-8,138422-11-4) + C18H15ClO (138422-07-8,138422-11-4)

Guidance literature:

In neat (no solvent); for 0.5h; Yields of byproduct given; Heating;

DOI:10.1016/S0040-4020(01)91007-5

upstream raw materials:

diazomethane

(Z)-2-(4-Chlorobenzylidene)-1-tetralone

E-2-(4-chlorobenzylidene)-1-tetralone

Downstream raw materials:

Z-2-(α-methyl-4-chlorobenzylidene)-1-tetralone

E-2-(α-methyl-4-chlorobenzylidene)-1-tetralone

cis-2-(4-chlorophenyl-cyclopropyl)-1-tetralone

C₁₈H₁₅ClO

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