2-(4-methoxyphenoxy)-2-fluoroacetic acid

Base Information

• Chemical Name: 2-(4-methoxyphenoxy)-2-fluoroacetic acid
• CAS No.: 1432474-20-8
• Molecular Formula: C₉H₉FO₄
• Molecular Weight: 200.166
• Mol file: 1432474-20-8.mol

Synonyms:

Chemical Property of 2-(4-methoxyphenoxy)-2-fluoroacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-methoxyphenoxy)-2-fluoroacetic acid

There total 2 articles about 2-(4-methoxyphenoxy)-2-fluoroacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C11H13FO4 (1435486-08-0) → 2-(4-methoxyphenoxy)-2-fluoroacetic acid (1432474-20-8)

Guidance literature:

C₁₁H₁₃FO₄; With water; sodium hydroxide; In methanol; at 20 ℃; for 2h; Inert atmosphere;

With hydrogenchloride; In water; pH=2 - 7; Inert atmosphere;

DOI:10.1002/anie.201206352

Reference yield:

4-methoxy-phenol (150-76-5) → 2-(4-methoxyphenoxy)-2-fluoroacetic acid (1432474-20-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

2.1: sodium hydroxide; water / methanol / 2 h / 20 °C / Inert atmosphere

2.2: pH 2 - 7 / Inert atmosphere

With water; potassium carbonate; sodium hydroxide; In methanol; N,N-dimethyl-formamide;

DOI:10.1002/anie.201206352

upstream raw materials:

4-methoxy-phenol

C₁₁H₁₃FO₄