Technology Process of (S)-1-phenethyl-3,4-dihydro-1H-isochromene
There total 12 articles about (S)-1-phenethyl-3,4-dihydro-1H-isochromene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium 10% on activated carbon; hydrogen;
In
methanol;
at 20 ℃;
for 2.5h;
under 760.051 Torr;
optical yield given as %ee;
Inert atmosphere;
DOI:10.1021/ja207585p
- Guidance literature:
-
With
methyldi-t-butylphosphine; potassium tert-butylate; palladium diacetate;
In
tert-Amyl alcohol;
at 20 ℃;
for 24h;
optical yield given as %ee;
Inert atmosphere;
DOI:10.1021/ja207585p
- Guidance literature:
-
Multi-step reaction with 6 steps
1: dimethylsulfide borane complex / tetrahydrofuran / 1 h / Inert atmosphere; Reflux
2: toluene-4-sulfonic acid; lithium bromide / 24 h / Inert atmosphere; Reflux
3: trimethylsilyl trifluoromethanesulfonate / acetonitrile / 0 - 20 °C / Inert atmosphere
4: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 24 h / 20 °C / Inert atmosphere
5: copper(l) iodide; trimethylsilyl trifluoromethanesulfonate; triethylamine / 20 °C / Inert atmosphere
6: palladium 10% on activated carbon; hydrogen / methanol / 2.5 h / 20 °C / 760.05 Torr / Inert atmosphere
With
copper(l) iodide; trimethylsilyl trifluoromethanesulfonate; dimethylsulfide borane complex; palladium 10% on activated carbon; hydrogen; toluene-4-sulfonic acid; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium bromide;
In
tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1021/ja207585p
