(2R)-2-[2-chloro-5-[[3-(4-tert-butylphenyl)-2-oxo-6-trifluoromethylbenzimidazol-1-yl]methyl]phenoxy]propanoic acid

Base Information

• Chemical Name: (2R)-2-[2-chloro-5-[[3-(4-tert-butylphenyl)-2-oxo-6-trifluoromethylbenzimidazol-1-yl]methyl]phenoxy]propanoic acid
• CAS No.: 1351534-14-9
• Molecular Formula: C₂₈H₂₆ClF₃N₂O₄
• Molecular Weight: 546.974
• Mol file: 1351534-14-9.mol

Synonyms:

Chemical Property of (2R)-2-[2-chloro-5-[[3-(4-tert-butylphenyl)-2-oxo-6-trifluoromethylbenzimidazol-1-yl]methyl]phenoxy]propanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R)-2-[2-chloro-5-[[3-(4-tert-butylphenyl)-2-oxo-6-trifluoromethylbenzimidazol-1-yl]methyl]phenoxy]propanoic acid

There total 5 articles about (2R)-2-[2-chloro-5-[[3-(4-tert-butylphenyl)-2-oxo-6-trifluoromethylbenzimidazol-1-yl]methyl]phenoxy]propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C23H25F3N2O3 → (2R)-2-[2-chloro-5-[[3-(4-tert-butylphenyl)-2-oxo-6-trifluoromethylbenzimidazol-1-yl]methyl]phenoxy]propanoic acid (1351534-14-9)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / 3 h / 20 °C

2: caesium carbonate / N,N-dimethyl-formamide / 20 °C

With caesium carbonate; trifluoroacetic acid; In N,N-dimethyl-formamide;

DOI:10.1021/jm201061j

Reference yield:

(2R)-(2-chloro-5-methylphenoxy)propanoic acid methyl ester (1351534-06-9) → (2R)-2-[2-chloro-5-[[3-(4-tert-butylphenyl)-2-oxo-6-trifluoromethylbenzimidazol-1-yl]methyl]phenoxy]propanoic acid (1351534-14-9)

Guidance literature:

Multi-step reaction with 2 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 16 h / Heating; Inert atmosphere

2: caesium carbonate / N,N-dimethyl-formamide / 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); caesium carbonate; In tetrachloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm201061j

Reference yield:

2-chloro-5-methylphenol (615-74-7) → (2R)-2-[2-chloro-5-[[3-(4-tert-butylphenyl)-2-oxo-6-trifluoromethylbenzimidazol-1-yl]methyl]phenoxy]propanoic acid (1351534-14-9)

Guidance literature:

Multi-step reaction with 3 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C

2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 16 h / Heating; Inert atmosphere

3: caesium carbonate / N,N-dimethyl-formamide / 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); di-isopropyl azodicarboxylate; caesium carbonate; triphenylphosphine; In tetrahydrofuran; tetrachloromethane; N,N-dimethyl-formamide; 1: Mitsunobu reaction;

DOI:10.1021/jm201061j

upstream raw materials:

(2R)-(2-chloro-5-methylphenoxy)propanoic acid methyl ester

2-chloro-5-methylphenol

2,3-Dihydro-2-oxo-6-(trifluoromethyl)-1H-benzimidazole-1-carboxylic acid 1,1-dimethylethyl ester

5-(trifluoromethyl)-1,3-dihydro-2H-benzoimidazol-2-one