C₂₂H₂₇F₃O₅

Base Information

• Chemical Name: C₂₂H₂₇F₃O₅
• CAS No.: 1427351-57-2
• Molecular Formula: C₂₂H₂₇F₃O₅
• Molecular Weight: 428.449
• Mol file: 1427351-57-2.mol

Synonyms:

Chemical Property of C₂₂H₂₇F₃O₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₂H₂₇F₃O₅

There total 2 articles about C₂₂H₂₇F₃O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 4-methyl-4-pentenoate (4911-54-0) → C22H27F3O5 (1427351-57-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 4 h / Inert atmosphere; Schlenk technique; Reflux

2.1: (+)-diisopinocampheylallylborane / diethyl ether / 3.5 h / -100 °C / Inert atmosphere; Schlenk technique

2.2: 1 h / Inert atmosphere; Schlenk technique; Reflux

3.1: triethylamine; 2,4,6-trichlorobenzoyl chloride; dmap / toluene / 3 h / 0 - 23 °C / Inert atmosphere; Schlenk technique

With dmap; Hoveyda-Grubbs catalyst second generation; 2,4,6-trichlorobenzoyl chloride; (+)-diisopinocampheylallylborane; triethylamine; In diethyl ether; dichloromethane; toluene;

DOI:10.1039/c2ob26906f

Reference yield:

(E)-ethyl 4-methyl-6-oxohex-4-enoate (1427351-54-9) → C22H27F3O5 (1427351-57-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: (+)-diisopinocampheylallylborane / diethyl ether / 3.5 h / -100 °C / Inert atmosphere; Schlenk technique

1.2: 1 h / Inert atmosphere; Schlenk technique; Reflux

2.1: triethylamine; 2,4,6-trichlorobenzoyl chloride; dmap / toluene / 3 h / 0 - 23 °C / Inert atmosphere; Schlenk technique

With dmap; 2,4,6-trichlorobenzoyl chloride; (+)-diisopinocampheylallylborane; triethylamine; In diethyl ether; toluene;

DOI:10.1039/c2ob26906f

upstream raw materials:

ethyl 4-methyl-4-pentenoate

(E)-ethyl 4-methyl-6-oxohex-4-enoate