Technology Process of 1-[3-bromo-4-(fluoromethyl)benzyl]guanidine trfluoroacetic acid salt
There total 6 articles about 1-[3-bromo-4-(fluoromethyl)benzyl]guanidine trfluoroacetic acid salt which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 48 h / Reflux
2: dimethyl sulfoxide / water / 6 h / 120 °C
3: sodium tetrahydroborate; methanol / 0.67 h / 0 °C
4: lithium aluminium tetrahydride / tetrahydrofuran; methanol / 16 h / 0 - 20 °C
5: acetonitrile / 0.5 h / 20 °C
6: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane; tetrahydrofuran / 3 h / -78 °C
7: hydrogenchloride / water; 1,4-dioxane / 1 h / 20 °C
With
hydrogenchloride; methanol; sodium tetrahydroborate; N-Bromosuccinimide; lithium aluminium tetrahydride; dimethyl sulfoxide; (bis-(2-methoxyethyl)amino)sulfur trufluoride; dibenzoyl peroxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; dichloromethane; water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: dimethyl sulfoxide / water / 6 h / 120 °C
2: sodium tetrahydroborate; methanol / 0.67 h / 0 °C
3: lithium aluminium tetrahydride / tetrahydrofuran; methanol / 16 h / 0 - 20 °C
4: acetonitrile / 0.5 h / 20 °C
5: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane; tetrahydrofuran / 3 h / -78 °C
6: hydrogenchloride / water; 1,4-dioxane / 1 h / 20 °C
With
hydrogenchloride; methanol; sodium tetrahydroborate; lithium aluminium tetrahydride; dimethyl sulfoxide; (bis-(2-methoxyethyl)amino)sulfur trufluoride;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: acetonitrile / 0.5 h / 20 °C
2: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane; tetrahydrofuran / 3 h / -78 °C
3: hydrogenchloride / water; 1,4-dioxane / 1 h / 20 °C
With
hydrogenchloride; (bis-(2-methoxyethyl)amino)sulfur trufluoride;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetonitrile;
