Technology Process of (1S,2R,3R)-3-Hydroxy-2,11-dimethoxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydro-indolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester
There total 26 articles about (1S,2R,3R)-3-Hydroxy-2,11-dimethoxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydro-indolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
tetrahydrofuran;
at 20 ℃;
for 30h;
DOI:10.1021/ja055744x
- Guidance literature:
-
With
hydrogenchloride;
In
tetrahydrofuran;
at 20 ℃;
DOI:10.1021/ja055744x
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 98 percent / H2 / Pd/C / ethyl acetate / 30 h / 760 Torr
2: 72 percent / pyridine; 4-dimethylaminopyridine / CH2Cl2 / 10 h / Heating
3: 60.5 percent / m-chloroperbenzoic acid; Na2PO4 / CH2Cl2 / 15 h / 20 °C
4: 96 percent / Ag2O; CaSO4 / 20 h
5: 84 percent / diisobutylaluminum hydride / diethyl ether; tetrahydrofuran / 0.5 h / -78 °C
6: 87 percent / MgSO4 / acetonitrile / 1 h
7: 92 percent / aq. HCl / tetrahydrofuran / 30 h / 20 °C
With
pyridine; hydrogenchloride; dmap; calcium sulfate; hydrogen; diisobutylaluminium hydride; magnesium sulfate; 3-chloro-benzenecarboperoxoic acid; silver(l) oxide;
palladium on activated charcoal;
In
tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate; acetonitrile;
6: Strecker reaction;
DOI:10.1021/ja055744x