Methanesulfonic acid (1S,4S,5S,6S)-6-(4-methoxy-benzyloxy)-4-methoxymethoxy-1-[(S)-1-(methoxy-methyl-carbamoyl)-ethyl]-5-methyl-octyl ester

Base Information

• Chemical Name: Methanesulfonic acid (1S,4S,5S,6S)-6-(4-methoxy-benzyloxy)-4-methoxymethoxy-1-[(S)-1-(methoxy-methyl-carbamoyl)-ethyl]-5-methyl-octyl ester
• CAS No.: 274263-54-6
• Molecular Formula: C₂₅H₄₃NO₉S
• Molecular Weight: 533.684
• Mol file: 274263-54-6.mol

Synonyms:

Chemical Property of Methanesulfonic acid (1S,4S,5S,6S)-6-(4-methoxy-benzyloxy)-4-methoxymethoxy-1-[(S)-1-(methoxy-methyl-carbamoyl)-ethyl]-5-methyl-octyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methanesulfonic acid (1S,4S,5S,6S)-6-(4-methoxy-benzyloxy)-4-methoxymethoxy-1-[(S)-1-(methoxy-methyl-carbamoyl)-ethyl]-5-methyl-octyl ester

There total 5 articles about Methanesulfonic acid (1S,4S,5S,6S)-6-(4-methoxy-benzyloxy)-4-methoxymethoxy-1-[(S)-1-(methoxy-methyl-carbamoyl)-ethyl]-5-methyl-octyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-Methyl-3-oxo-pent-4-enoic acid methoxy-methyl-amide (274263-47-7) → Methanesulfonic acid (1S,4S,5S,6S)-6-(4-methoxy-benzyloxy)-4-methoxymethoxy-1-[(S)-1-(methoxy-methyl-carbamoyl)-ethyl]-5-methyl-octyl ester (274263-54-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: n-BuLi

1.2: 45 percent / Li⁽¹⁺⁾*Th-Cu-CN^(1-)

2.1: KB(Et)3H

With n-butyllithium; potassium triethylborohydride; 1.1: transmetallation / 1.2: Metallation / 1.3: Addition / 2.1: Reduction / 3.1: mesylation;

DOI:10.1021/ol005714t

Reference yield:

methylketene dimer (476365-41-0) → Methanesulfonic acid (1S,4S,5S,6S)-6-(4-methoxy-benzyloxy)-4-methoxymethoxy-1-[(S)-1-(methoxy-methyl-carbamoyl)-ethyl]-5-methyl-octyl ester (274263-54-6)

Guidance literature:

Multi-step reaction with 5 steps

2.1: Pd(OAc)2

3.1: n-BuLi

3.2: 45 percent / Li⁽¹⁺⁾*Th-Cu-CN^(1-)

4.1: KB(Et)3H

With palladium diacetate; n-butyllithium; potassium triethylborohydride; 1.1: Addition / 1.2: silylation / 2.1: Oxidation / 3.1: transmetallation / 3.2: Metallation / 3.3: Addition / 4.1: Reduction / 5.1: mesylation;

DOI:10.1021/ol005714t

Reference yield:

(Z)-(S)-2-Methyl-3-trimethylsilanyloxy-pent-3-enoic acid methoxy-methyl-amide → Methanesulfonic acid (1S,4S,5S,6S)-6-(4-methoxy-benzyloxy)-4-methoxymethoxy-1-[(S)-1-(methoxy-methyl-carbamoyl)-ethyl]-5-methyl-octyl ester (274263-54-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: Pd(OAc)2

2.1: n-BuLi

2.2: 45 percent / Li⁽¹⁺⁾*Th-Cu-CN^(1-)

3.1: KB(Et)3H

With palladium diacetate; n-butyllithium; potassium triethylborohydride; 1.1: Oxidation / 2.1: transmetallation / 2.2: Metallation / 2.3: Addition / 3.1: Reduction / 4.1: mesylation;

DOI:10.1021/ol005714t

upstream raw materials:

methanesulfonyl chloride

methylketene dimer

(S)-2-Methyl-3-oxo-pent-4-enoic acid methoxy-methyl-amide

(2S,6S,7S,8S)-8-(4-Methoxy-benzyloxy)-6-methoxymethoxy-2,7-dimethyl-3-oxo-decanoic acid methoxy-methyl-amide