(R,R)-N,N'-bis(5-methyl-3-phenylsalicyl)-1,2-cyclohexanediamine

Base Information

• Chemical Name: (R,R)-N,N'-bis(5-methyl-3-phenylsalicyl)-1,2-cyclohexanediamine
• CAS No.: 1333500-75-6
• Molecular Formula: C₃₄H₃₈N₂O₂
• Molecular Weight: 506.688
• Mol file: 1333500-75-6.mol

Synonyms:

Chemical Property of (R,R)-N,N'-bis(5-methyl-3-phenylsalicyl)-1,2-cyclohexanediamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R,R)-N,N'-bis(5-methyl-3-phenylsalicyl)-1,2-cyclohexanediamine

There total 5 articles about (R,R)-N,N'-bis(5-methyl-3-phenylsalicyl)-1,2-cyclohexanediamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-methyl-2-hydroxy-3-phenyl benzaldehyde (277313-14-1) → (R,R)-N,N'-bis(5-methyl-3-phenylsalicyl)-1,2-cyclohexanediamine (1333500-75-6)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol; dichloromethane / 1 h / 20 °C

2: sodium tetrahydroborate / 16 h

With sodium tetrahydroborate; In methanol; dichloromethane;

DOI:10.1002/ejoc.201100557

Reference yield:

2-Phenylphenol (90-43-7,287950-96-3) → (R,R)-N,N'-bis(5-methyl-3-phenylsalicyl)-1,2-cyclohexanediamine (1333500-75-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: triethylamine; magnesium chloride / acetonitrile / 0.25 h / Inert atmosphere

1.2: 24 h / 75 °C / Inert atmosphere

2.1: hydrogenchloride / water / 100 °C

3.1: hydrogenchloride; tin(II) chloride dihdyrate / 1,4-dioxane; water / 3.5 h / Reflux

4.1: methanol; dichloromethane / 1 h / 20 °C

5.1: sodium tetrahydroborate / 16 h

With hydrogenchloride; sodium tetrahydroborate; tin(II) chloride dihdyrate; triethylamine; magnesium chloride; In 1,4-dioxane; methanol; dichloromethane; water; acetonitrile;

DOI:10.1002/ejoc.201100557

Reference yield:

5-(chloromethyl)-2-hydroxy-3-phenylbenzaldehyde (1046158-72-8) → (R,R)-N,N'-bis(5-methyl-3-phenylsalicyl)-1,2-cyclohexanediamine (1333500-75-6)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride; tin(II) chloride dihdyrate / 1,4-dioxane; water / 3.5 h / Reflux

2: methanol; dichloromethane / 1 h / 20 °C

3: sodium tetrahydroborate / 16 h

With hydrogenchloride; sodium tetrahydroborate; tin(II) chloride dihdyrate; In 1,4-dioxane; methanol; dichloromethane; water;

DOI:10.1002/ejoc.201100557

upstream raw materials:

5-(chloromethyl)-2-hydroxy-3-phenylbenzaldehyde

5-methyl-2-hydroxy-3-phenyl benzaldehyde

2-hydroxy-3-phenylbenzaldehyde

2-Phenylphenol