6-bromo-N-(2-(cyclohexylamino)-1-(2-((1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-2-oxoethyl)-2-oxo-N-phenyl-2H-chromene-3-carboxamide

Base Information

• Chemical Name: 6-bromo-N-(2-(cyclohexylamino)-1-(2-((1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-2-oxoethyl)-2-oxo-N-phenyl-2H-chromene-3-carboxamide
• CAS No.: 1569352-13-1
• Molecular Formula: C₃₉H₃₃BrN₆O₇
• Molecular Weight: 777.631
• Mol file: 1569352-13-1.mol

Synonyms:

Chemical Property of 6-bromo-N-(2-(cyclohexylamino)-1-(2-((1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-2-oxoethyl)-2-oxo-N-phenyl-2H-chromene-3-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-bromo-N-(2-(cyclohexylamino)-1-(2-((1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-2-oxoethyl)-2-oxo-N-phenyl-2H-chromene-3-carboxamide

There total 3 articles about 6-bromo-N-(2-(cyclohexylamino)-1-(2-((1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-2-oxoethyl)-2-oxo-N-phenyl-2H-chromene-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C33H29BrN2O5 + p-nitrobenzyl azide (17271-88-4) → 6-bromo-N-(2-(cyclohexylamino)-1-(2-((1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-2-oxoethyl)-2-oxo-N-phenyl-2H-chromene-3-carboxamide (1569352-13-1)

Guidance literature:

With copper diacetate; sodium L-ascorbate; In ethanol; at 20 ℃; for 6h;

DOI:10.1021/co4001259

Reference yield:

5-bromosalicyclaldehyde (1761-61-1) → 6-bromo-N-(2-(cyclohexylamino)-1-(2-((1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-2-oxoethyl)-2-oxo-N-phenyl-2H-chromene-3-carboxamide (1569352-13-1)

Guidance literature:

Multi-step reaction with 3 steps

1: ethanol / 10 h / 20 °C

2: ethanol / 8 h / 20 °C

3: copper diacetate; sodium L-ascorbate / ethanol / 6 h / 20 °C

With copper diacetate; sodium L-ascorbate; In ethanol; 1: |Knoevenagel Condensation / 2: |Ugi Condensation / 3: |Huisgen Cycloaddition;

DOI:10.1021/co4001259

Reference yield:

6-bromocoumarin-3-carboxylic acid (2199-87-3) → 6-bromo-N-(2-(cyclohexylamino)-1-(2-((1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-2-oxoethyl)-2-oxo-N-phenyl-2H-chromene-3-carboxamide (1569352-13-1)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 8 h / 20 °C

2: copper diacetate; sodium L-ascorbate / ethanol / 6 h / 20 °C

With copper diacetate; sodium L-ascorbate; In ethanol; 1: |Ugi Condensation / 2: |Huisgen Cycloaddition;

DOI:10.1021/co4001259

upstream raw materials:

5-bromosalicyclaldehyde

p-nitrobenzyl azide

6-bromocoumarin-3-carboxylic acid