Technology Process of (R)-2-(o-tolyl)propan-1-amine
There total 4 articles about (R)-2-(o-tolyl)propan-1-amine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
L-alanin; formate dehydrogenase from Candida boidinii; L-alanine dehydrogenase from Bacillus subtilis; pyridoxal 5'-phosphate; ω-transaminase form Arthrobacter species S; ammonium formate; NADH;
In
aq. phosphate buffer;
at 30 ℃;
for 24h;
Reagent/catalyst;
Overall yield = 90 %Chromat.; stereoselective reaction;
Resolution of racemate;
Enzymatic reaction;
DOI:10.1002/adsc.201400217
- Guidance literature:
-
With
L-alanin; formate dehydrogenase from Candida boidinii; L-alanine dehydrogenase from Bacillus subtilis; pyridoxal 5'-phosphate; ω-transaminase form Pseudomonas pudita1; ammonium formate; NADH;
In
aq. phosphate buffer;
at 30 ℃;
for 24h;
Reagent/catalyst;
stereoselective reaction;
Resolution of racemate;
Enzymatic reaction;
DOI:10.1002/adsc.201400217
- Guidance literature:
-
Multi-step reaction with 2 steps
1: dodecacarbonyltetrarhodium(0); hydrogen / toluene / 96 h / 40 °C / 7500.75 - 30003 Torr / Autoclave; Inert atmosphere
2: pyridoxal 5'-phosphate; ω-transaminase form Pseudomonas pudita1; formate dehydrogenase from Candida boidinii; NADH; L-alanine dehydrogenase from Bacillus subtilis; ammonium formate; L-alanin / aq. phosphate buffer / 24 h / 30 °C / Resolution of racemate; Enzymatic reaction
With
dodecacarbonyltetrarhodium(0); L-alanin; formate dehydrogenase from Candida boidinii; L-alanine dehydrogenase from Bacillus subtilis; pyridoxal 5'-phosphate; ω-transaminase form Pseudomonas pudita1; hydrogen; ammonium formate; NADH;
In
aq. phosphate buffer; toluene;
DOI:10.1002/adsc.201400217
