C₂₅H₂₂FNO₃

Base Information

• Chemical Name: C₂₅H₂₂FNO₃
• CAS No.: 1403674-94-1
• Molecular Formula: C₂₅H₂₂FNO₃
• Molecular Weight: 403.453
• Mol file: 1403674-94-1.mol

Synonyms:

Chemical Property of C₂₅H₂₂FNO₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₅H₂₂FNO₃

There total 7 articles about C₂₅H₂₂FNO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

3-(2-fluoro-4-methoxyphenyl)-2,5-bis(4-methoxyphenyl)-1-propyl-1H-pyrrole (1403674-82-7) → C25H22FNO3 (1403674-94-1)

Guidance literature:

With boron tribromide; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/jm300860j

Reference yield:

2-fluoro-4-methoxy-benzaldehyde (331-64-6) → C25H22FNO3 (1403674-94-1)

Guidance literature:

Multi-step reaction with 7 steps

1.1: potassium hydroxide / N,N-dimethyl-formamide; methanol / -9 - -8 °C / Inert atmosphere

1.2: 0.5 h / -5 °C

2.1: diphenyl diselenide; sodium tetrahydroborate; ethanol; sodium hydroxide / 40 °C / Inert atmosphere

3.1: thionyl chloride / 1 h / Reflux

4.1: aluminum (III) chloride / dichloromethane / 1 h / 20 °C

5.1: potassium hexamethylsilazane / toluene; tetrahydrofuran / 1 h / -78 °C

5.2: -78 - 20 °C

6.1: toluene-4-sulfonic acid / ethanol / 72 h / Reflux

7.1: boron tribromide / 0 - 20 °C / Inert atmosphere

With aluminum (III) chloride; sodium tetrahydroborate; thionyl chloride; ethanol; diphenyl diselenide; boron tribromide; potassium hexamethylsilazane; toluene-4-sulfonic acid; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; 4.1: |Friedel-Crafts Acylation;

DOI:10.1021/jm300860j

Reference yield:

2-Bromo-4'-methoxyacetophenone (2632-13-5) → C25H22FNO3 (1403674-94-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium hexamethylsilazane / toluene; tetrahydrofuran / 1 h / -78 °C

1.2: -78 - 20 °C

2.1: toluene-4-sulfonic acid / ethanol / 72 h / Reflux

3.1: boron tribromide / 0 - 20 °C / Inert atmosphere

With boron tribromide; potassium hexamethylsilazane; toluene-4-sulfonic acid; In tetrahydrofuran; ethanol; toluene;

DOI:10.1021/jm300860j

upstream raw materials:

2-fluoro-4-methoxy-benzaldehyde

2-(2-fluoro-4-methoxyphenyl)acetic acid

2-(2-fluoro-4-methoxyphenyl)acetic acid chloride

2-Bromo-4'-methoxyacetophenone