3-(1-Benzoyl-1,2,2a,3-tetrahydro-benzo[cd]indol-5-yl)-2-[(tert-butoxycarbonyl-methyl-amino)-methyl]-3-methanesulfonyloxy-propionic acid ethyl ester

Base Information

Chemical Name:3-(1-Benzoyl-1,2,2a,3-tetrahydro-benzo[cd]indol-5-yl)-2-[(tert-butoxycarbonyl-methyl-amino)-methyl]-3-methanesulfonyloxy-propionic acid ethyl ester
CAS No.:107206-03-1
Molecular Formula:C₃₁H₃₈N₂O₈S
Molecular Weight:598.717
Hs Code.:

3-(1-Benzoyl-1,2,2a,3-tetrahydro-benzo[cd]indol-5-yl)-2-[(tert-butoxycarbonyl-methyl-amino)-methyl]-3-methanesulfonyloxy-propionic acid ethyl ester

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Chemical Property of 3-(1-Benzoyl-1,2,2a,3-tetrahydro-benzo[cd]indol-5-yl)-2-[(tert-butoxycarbonyl-methyl-amino)-methyl]-3-methanesulfonyloxy-propionic acid ethyl ester

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Technology Process of 3-(1-Benzoyl-1,2,2a,3-tetrahydro-benzo[cd]indol-5-yl)-2-[(tert-butoxycarbonyl-methyl-amino)-methyl]-3-methanesulfonyloxy-propionic acid ethyl ester

There total 10 articles about 3-(1-Benzoyl-1,2,2a,3-tetrahydro-benzo[cd]indol-5-yl)-2-[(tert-butoxycarbonyl-methyl-amino)-methyl]-3-methanesulfonyloxy-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 107183-50-6
1-benzoyl-1,2,2a,3-tetrahydrobenzindole-5-carbonyl chloride

: 107206-03-1
3-(1-Benzoyl-1,2,2a,3-tetrahydro-benzo[cd]indol-5-yl)-2-[(tert-butoxycarbonyl-methyl-amino)-methyl]-3-methanesulfonyloxy-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 54 percent / H₂ / 10percent Pd-BaSO₄ / ethyl acetate; xylene / 2 h / 90 - 100 °C

2: 99 percent / LDA / tetrahydrofuran / 0.5 h / -78 °C

3: TEA / CH₂Cl₂ / 0.25 h / Ambient temperature

With TEA; hydrogen; lithium diisopropyl amide; palladium on barium sulfate; In tetrahydrofuran; dichloromethane; ethyl acetate; xylene;
DOI:10.1248/cpb.35.4793

Reference yield:

: 1,2,2a,3-tetrahydrobenzindole-5-carboxylic acid

: 107206-03-1
3-(1-Benzoyl-1,2,2a,3-tetrahydro-benzo[cd]indol-5-yl)-2-[(tert-butoxycarbonyl-methyl-amino)-methyl]-3-methanesulfonyloxy-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / 0.2N NaOH / 1 h / Ambient temperature

2: 100 percent / SOCl₂ / benzene / 2.5 h / 95 °C

3: 54 percent / H₂ / 10percent Pd-BaSO₄ / ethyl acetate; xylene / 2 h / 90 - 100 °C

4: 99 percent / LDA / tetrahydrofuran / 0.5 h / -78 °C

5: TEA / CH₂Cl₂ / 0.25 h / Ambient temperature

With sodium hydroxide; thionyl chloride; TEA; hydrogen; lithium diisopropyl amide; palladium on barium sulfate; In tetrahydrofuran; dichloromethane; ethyl acetate; xylene; benzene;
DOI:10.1248/cpb.35.4793

Reference yield:

: 117138-55-3
1-benzoyl-1,2,2a,3-tetrahydrobenzindole-5-carboxylic acid

: 107206-03-1
3-(1-Benzoyl-1,2,2a,3-tetrahydro-benzo[cd]indol-5-yl)-2-[(tert-butoxycarbonyl-methyl-amino)-methyl]-3-methanesulfonyloxy-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / SOCl₂ / benzene / 2.5 h / 95 °C

2: 54 percent / H₂ / 10percent Pd-BaSO₄ / ethyl acetate; xylene / 2 h / 90 - 100 °C

3: 99 percent / LDA / tetrahydrofuran / 0.5 h / -78 °C

4: TEA / CH₂Cl₂ / 0.25 h / Ambient temperature

With thionyl chloride; TEA; hydrogen; lithium diisopropyl amide; palladium on barium sulfate; In tetrahydrofuran; dichloromethane; ethyl acetate; xylene; benzene;
DOI:10.1248/cpb.35.4793