methyl 3β,16α-dihydroxy-24-norchol-5-en-23-oate 3,16-ditosylate

Base Information

• Chemical Name: methyl 3β,16α-dihydroxy-24-norchol-5-en-23-oate 3,16-ditosylate
• CAS No.: 87302-03-2
• Molecular Formula: C₃₈H₅₀O₈S₂
• Molecular Weight: 698.942
• Mol file: 87302-03-2.mol

Synonyms:

Chemical Property of methyl 3β,16α-dihydroxy-24-norchol-5-en-23-oate 3,16-ditosylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3β,16α-dihydroxy-24-norchol-5-en-23-oate 3,16-ditosylate

There total 3 articles about methyl 3β,16α-dihydroxy-24-norchol-5-en-23-oate 3,16-ditosylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Acetic acid (2S,10aR)-4a,6a,7-trimethyl-9-oxo-1,2,3,4,4a,4b,5,6,6a,8,9,10a,11,11a,11b,12-hexadecahydro-10-oxa-indeno[2,1-a]phenanthren-2-yl ester (58348-04-2,75023-90-4,123484-94-6) → methyl 3β,16α-dihydroxy-24-norchol-5-en-23-oate 3,16-ditosylate (87302-03-2)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / PtO₂ / acetic acid

2: 570 mg / aq. HCl / CHCl₃; H₂O / 50 h / 20 °C

3: pyridine / 48 h / 4 °C

With pyridine; hydrogenchloride; hydrogen; platinum(IV) oxide; In chloroform; water; acetic acid;

DOI:10.1007/BF00580553

Reference yield:

(2S,7R,10aR)-2-Hydroxy-4a,6a,7-trimethyl-2,3,4,4a,4b,5,6,6a,6b,7,8,10a,11,11a,11b,12-hexadecahydro-1H-10-oxa-indeno[2,1-a]phenanthren-9-one → methyl 3β,16α-dihydroxy-24-norchol-5-en-23-oate 3,16-ditosylate (87302-03-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 570 mg / aq. HCl / CHCl₃; H₂O / 50 h / 20 °C

2: pyridine / 48 h / 4 °C

With pyridine; hydrogenchloride; In chloroform; water;

DOI:10.1007/BF00580553

Reference yield:

methyl 3β,16α-dihydroxy-24-norchol-5-en-23-oate (87302-01-0) + p-toluenesulfonyl chloride (98-59-9) → methyl 3β,16α-dihydroxy-24-norchol-5-en-23-oate 3,16-ditosylate (87302-03-2)

Guidance literature:

With pyridine; at 4 ℃; for 48h; Yield given;

DOI:10.1007/BF00580553

upstream raw materials:

methyl 3β,16α-dihydroxy-24-norchol-5-en-23-oate

p-toluenesulfonyl chloride

Acetic acid (2S,10aR)-4a,6a,7-trimethyl-9-oxo-1,2,3,4,4a,4b,5,6,6a,8,9,10a,11,11a,11b,12-hexadecahydro-10-oxa-indeno[2,1-a]phenanthren-2-yl ester