(R)-4-Benzyl-3-((R)-2-{(4R,5S,6S)-6-[(S)-1-(6-ethyl-3,5-dimethyl-4-oxo-4H-pyran-2-yl)-ethyl]-2,2-diisopropyl-5-methyl-[1,3,2]dioxasilinan-4-yl}-propionyl)-oxazolidin-2-one

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Chemical Name:(R)-4-Benzyl-3-((R)-2-{(4R,5S,6S)-6-[(S)-1-(6-ethyl-3,5-dimethyl-4-oxo-4H-pyran-2-yl)-ethyl]-2,2-diisopropyl-5-methyl-[1,3,2]dioxasilinan-4-yl}-propionyl)-oxazolidin-2-one
CAS No.:895567-38-1
Molecular Formula:C₃₄H₄₉NO₇Si
Molecular Weight:611.851
Hs Code.:

(R)-4-Benzyl-3-((R)-2-{(4R,5S,6S)-6-[(S)-1-(6-ethyl-3,5-dimethyl-4-oxo-4H-pyran-2-yl)-ethyl]-2,2-diisopropyl-5-methyl-[1,3,2]dioxasilinan-4-yl}-propionyl)-oxazolidin-2-one

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Chemical Property of (R)-4-Benzyl-3-((R)-2-{(4R,5S,6S)-6-[(S)-1-(6-ethyl-3,5-dimethyl-4-oxo-4H-pyran-2-yl)-ethyl]-2,2-diisopropyl-5-methyl-[1,3,2]dioxasilinan-4-yl}-propionyl)-oxazolidin-2-one

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Technology Process of (R)-4-Benzyl-3-((R)-2-{(4R,5S,6S)-6-[(S)-1-(6-ethyl-3,5-dimethyl-4-oxo-4H-pyran-2-yl)-ethyl]-2,2-diisopropyl-5-methyl-[1,3,2]dioxasilinan-4-yl}-propionyl)-oxazolidin-2-one

There total 10 articles about (R)-4-Benzyl-3-((R)-2-{(4R,5S,6S)-6-[(S)-1-(6-ethyl-3,5-dimethyl-4-oxo-4H-pyran-2-yl)-ethyl]-2,2-diisopropyl-5-methyl-[1,3,2]dioxasilinan-4-yl}-propionyl)-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2S,4S,6R)-2-{(4S,5S,6R)-6-[(R)-2-((R)-4-Benzyl-2-oxo-oxazolidin-3-yl)-1-methyl-2-oxo-ethyl]-2,2-diisopropyl-5-methyl-[1,3,2]dioxasilinan-4-yl}-4,6-dimethyl-nonane-3,5,7-trione

: 895567-38-1
(R)-4-Benzyl-3-((R)-2-{(4R,5S,6S)-6-[(S)-1-(6-ethyl-3,5-dimethyl-4-oxo-4H-pyran-2-yl)-ethyl]-2,2-diisopropyl-5-methyl-[1,3,2]dioxasilinan-4-yl}-propionyl)-oxazolidin-2-one

Guidance literature:: With tetrachloromethane; triphenylphosphine; In tetrahydrofuran; for 72h;
DOI:10.1016/j.tetlet.2006.03.096

Reference yield:

: 4-methyl-5-triethylsilanyloxy-heptan-3-one

: 895567-38-1
(R)-4-Benzyl-3-((R)-2-{(4R,5S,6S)-6-[(S)-1-(6-ethyl-3,5-dimethyl-4-oxo-4H-pyran-2-yl)-ethyl]-2,2-diisopropyl-5-methyl-[1,3,2]dioxasilinan-4-yl}-propionyl)-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: TiCl₄; diisopropylethylamine / CH₂Cl₂ / 1.5 h / -78 °C

1.2: CH₂Cl₂ / -85 - -5 °C

2.1: Dess-Martin periodinane / CH₂Cl₂ / 4 h / 20 °C

3.1: Ph₃P; CCl₄ / tetrahydrofuran / 72 h

With tetrachloromethane; titanium tetrachloride; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; 1.2: aldol reaction;
DOI:10.1016/j.tetlet.2006.03.096

Reference yield:

: 141505-93-3
(2R,4S,5S)-1-((R)-4-Benzyl-2-oxo-oxazolidin-3-yl)-5-hydroxy-2,4,6-trimethyl-hept-6-ene-1,3-dione

: 895567-38-1
(R)-4-Benzyl-3-((R)-2-{(4R,5S,6S)-6-[(S)-1-(6-ethyl-3,5-dimethyl-4-oxo-4H-pyran-2-yl)-ethyl]-2,2-diisopropyl-5-methyl-[1,3,2]dioxasilinan-4-yl}-propionyl)-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: DIBAL-H / -78 °C

2.1: 2,6-lutidine / CH₂Cl₂ / 18 h / 25 °C

3.1: (ThexBH₂)2*TMEDA / tetrahydrofuran / 96 h / 20 - 40 °C

3.2: H₂O₂ / methanol; tetrahydrofuran / 2 h / 20 °C

3.3: 53 percent / PCC / CH₂Cl₂

4.1: TiCl₄; diisopropylethylamine / CH₂Cl₂ / 1.5 h / -78 °C

4.2: CH₂Cl₂ / -85 - -5 °C

5.1: Dess-Martin periodinane / CH₂Cl₂ / 4 h / 20 °C

6.1: Ph₃P; CCl₄ / tetrahydrofuran / 72 h

With 2,6-dimethylpyridine; tetrachloromethane; (ThexBH₂)2*TMEDA; titanium tetrachloride; diisobutylaluminium hydride; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; 4.2: aldol reaction;
DOI:10.1016/j.tetlet.2006.03.096