(3aR-trans)-5-Chloro-2,3,3a,12b-tetrahydro-2-Methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole-13C,d3 β-D-Glucopyranosiduronic Acid

Base Information

Chemical Name:(3aR-trans)-5-Chloro-2,3,3a,12b-tetrahydro-2-Methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole-13C,d3 β-D-Glucopyranosiduronic Acid
CAS No.:1391745-10-0
Molecular Formula:C₂₃H₂₄ClNO₇
Molecular Weight:465.864
Hs Code.:
Mol file:1391745-10-0.mol

Synonyms:

Suppliers and Price of (3aR-trans)-5-Chloro-2,3,3a,12b-tetrahydro-2-Methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole-13C,d3 β-D-Glucopyranosiduronic Acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Asenapine-13C,d3N-β-D-GlucuronideTrifluoroaceticAcidSalt
1mg
$ 225.00

Medical Isotopes, Inc.
Asenapine-13C,d3N-β-D-GlucuronideTrifluoroaceticAcidSalt
10 mg
$ 2800.00

Total 2 raw suppliers

Chemical Property of (3aR-trans)-5-Chloro-2,3,3a,12b-tetrahydro-2-Methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole-13C,d3 β-D-Glucopyranosiduronic Acid

Chemical Property:

Melting Point:>150°C (dec.)
Storage Temp.:Hygroscopic, -20°C Freezer, Under Inert Atmosphere
Solubility.:DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

95% ^*data from raw suppliers

Asenapine-13C,d3N-β-D-GlucuronideTrifluoroaceticAcidSalt ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Labelled Asenapine N-β-D-Glucuronide (A788005). Asenapine N-β-D-Glucuronide is a metabolite of Asenapine (A788000).

Technology Process of (3aR-trans)-5-Chloro-2,3,3a,12b-tetrahydro-2-Methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole-13C,d3 β-D-Glucopyranosiduronic Acid

There total 2 articles about (3aR-trans)-5-Chloro-2,3,3a,12b-tetrahydro-2-Methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole-13C,d3 β-D-Glucopyranosiduronic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: ⁽¹³⁾CD₃OTf

: C₃₅H₄₂ClNO₁₀

: C₂₂⁽¹³⁾CH₁₉⁽²⁾H₃ClNO₆

: 1391745-10-0
[(13)CD3]-2-((3R,4S,5S,6S)-6-carboxy-3,4,5-trihydroxy-tetrahydro-2H-pyran-2-yl)-5-chloro-2-methyl-2,3,3a,12b-tetrahydro1-H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrol

Guidance literature:: ⁽¹³⁾CD₃OTf; C₃₅H₄₂ClNO₁₀; In dichloromethane; at 50 ℃; for 20h; Inert atmosphere;

With sodium carbonate; In methanol; water; at 20 ℃; for 18h;
DOI:10.1002/jlcr.2924

Reference yield:

: 128915-56-0,136085-14-8,136085-16-0,136085-18-2
trans-5-chloro-2,3,3a,12b-tetrahydro-1H-dibenz<2,3:6,7>oxepino<4,5-c>pyrrole

: methyl 2,3,4-tri-O-isobutyryl-D-glucopyranuronate

: C₂₂⁽¹³⁾CH₁₉⁽²⁾H₃ClNO₆

: 1391745-10-0
[(13)CD3]-2-((3R,4S,5S,6S)-6-carboxy-3,4,5-trihydroxy-tetrahydro-2H-pyran-2-yl)-5-chloro-2-methyl-2,3,3a,12b-tetrahydro1-H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrol

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene / 18 h / 50 °C / Inert atmosphere

2.1: dichloromethane / 20 h / 50 °C / Inert atmosphere

2.2: 18 h / 20 °C

In dichloromethane; toluene;
DOI:10.1002/jlcr.2924