(S)-N⁴-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-N²,N²-dimethyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2,4-dicarboxamide

Base Information

• Chemical Name: (S)-N⁴-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-N²,N²-dimethyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2,4-dicarboxamide
• CAS No.: 1403335-05-6
• Molecular Formula: C₂₆H₃₃ClFN₇O₃Si
• Molecular Weight: 574.13

Synonyms:

Chemical Property of (S)-N⁴-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-N²,N²-dimethyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2,4-dicarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N⁴-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-N²,N²-dimethyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2,4-dicarboxamide

There total 8 articles about (S)-N⁴-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-N²,N²-dimethyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2,4-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-6-fluoro-4-(1H-pyrazol-3-yl)benzonitrile (1297540-76-1) → (S)-N4-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-N2,N2-dimethyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2,4-dicarboxamide (1403335-05-6)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogenchloride; diisopropyl (E)-azodicarboxylate; triphenylphosphine / water; ethyl acetate

3: sodium hydroxide

With hydrogenchloride; sodium hydroxide; diisopropyl (E)-azodicarboxylate; triphenylphosphine; In water; ethyl acetate;

Reference yield:

4-benzyl 2-ethyl 1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2,4-dicarboxylate (1403334-98-4) → (S)-N4-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-N2,N2-dimethyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2,4-dicarboxamide (1403335-05-6)

Guidance literature:

Multi-step reaction with 4 steps

3: sodium hydroxide

With sodium hydroxide;

Reference yield:

2-(ethoxycarbonyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-4-carboxylic acid (1403335-00-1) → (S)-N4-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-N2,N2-dimethyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2,4-dicarboxamide (1403335-05-6)

Guidance literature:

Multi-step reaction with 3 steps

2: sodium hydroxide

With sodium hydroxide;

upstream raw materials:

benzyl-2-bromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-4-carboxylate

2-bromo-1-((2-(trimethyl-silyl)ethoxy)methyl)-1H-imidazole-4-carboxylic acid

4-benzyl 2-ethyl 1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2,4-dicarboxylate

2-(ethoxycarbonyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-4-carboxylic acid

Downstream raw materials:

(S)-N⁴-(1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-N²,N²-dimethyl-1H-imidazole-2,4-dicarboxamide

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