Fmoc-D-Phg-MePhe-Thz-OTmse

Base Information

• Chemical Name: Fmoc-D-Phg-MePhe-Thz-OTmse
• CAS No.: 120061-01-0
• Molecular Formula: C₄₂H₄₇N₃O₆SSi
• Molecular Weight: 750.003
• Mol file: 120061-01-0.mol

Synonyms:

Chemical Property of Fmoc-D-Phg-MePhe-Thz-OTmse

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Fmoc-D-Phg-MePhe-Thz-OTmse

There total 14 articles about Fmoc-D-Phg-MePhe-Thz-OTmse which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

N-(9-Fluorenylmethyloxy)carbonyl-L-phenylglycine (102410-65-1,111524-95-9,163883-97-4) + MePhe-Thz-OTmse*HCl (120060-99-3) → Fmoc-Phg-MePhe-Thz-OTmse (120061-01-0,120199-70-4) + Fmoc-D-Phg-MePhe-Thz-OTmse (120061-01-0,120199-70-4)

Guidance literature:

With 4-methyl-morpholine; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; In tetrahydrofuran; at 4 ℃; for 48h; Title compound not separated from byproducts;

Reference yield: 88.0%

N-(9-Fluorenylmethyloxy)carbonyl-L-phenylglycine (102410-65-1,111524-95-9,163883-97-4) + MePhe-Thz-OTmse*HCl (120060-99-3) → Fmoc-Phg-MePhe-Thz-OTmse (120061-01-0,120199-70-4) + Fmoc-D-Phg-MePhe-Thz-OTmse (120061-01-0,120199-70-4)

Guidance literature:

With 4-methyl-morpholine; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; In tetrahydrofuran; at 4 ℃; for 48h; Title compound not separated from byproducts;

Reference yield:

2-(Trimethylsilyl)ethanol (2916-68-9) → Fmoc-Phg-MePhe-Thz-OTmse (120061-01-0,120199-70-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 100 percent / 72 h / 4 °C

2: 85 percent formic acid / 24 h / Ambient temperature

3: 46 percent / BopCl, NMM / tetrahydrofuran / 0 - 4 °C

4: 98 percent / 1.2 N aq. HCl / various solvent(s) / 1 h

5: 88 percent / BopCl, NMM / tetrahydrofuran / 48 h / 4 °C

With 4-methyl-morpholine; hydrogenchloride; formic acid; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; In tetrahydrofuran;

upstream raw materials:

N-(9-Fluorenylmethyloxy)carbonyl-L-phenylglycine

MePhe-Thz-OTmse*HCl

2-(Trimethylsilyl)ethanol

N-tert-butoxycarbonyl-L-phenylalanine

Downstream raw materials:

Phg-MePhe-Thz

Phg-MePhe-Thz-OTmse

Refernces