3-Isobutylisoxazol-5-amine

Base Information

• Chemical Name: 3-Isobutylisoxazol-5-amine
• CAS No.: 1057064-36-4
• Molecular Formula: C₇H₁₂N₂O
• Molecular Weight: 140.185
• Hs Code.: 2934999090
• Mol file: 1057064-36-4.mol

Synonyms:

Chemical Property of 3-Isobutylisoxazol-5-amine

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

3-Isobutylisoxazol-5-amine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Isobutylisoxazol-5-amine

There total 3 articles about 3-Isobutylisoxazol-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

5-methyl-3-oxo-hexanenitrile (64373-43-9) → 3-isobutyl-isoxazol-5-ylamine (1057064-36-4)

Guidance literature:

5-methyl-3-oxo-hexanenitrile; With hydroxyammonium sulfate; sodium hydroxide; In water; at 20 - 100 ℃; for 1.5h; pH=8 - 11; Inert atmosphere;

With hydrogenchloride; In water; at 100 ℃; for 0.25h; Inert atmosphere;

DOI:10.1055/s-0032-1317935

Reference yield:

5-isobutyl-isoxazole (100859-56-1) → 3-isobutyl-isoxazol-5-ylamine (1057064-36-4)

Guidance literature:

With methanol; sodium methylate; Erwaermen mit NH₂OH+HCl in wss. Aethanol;

Reference yield:

→ 3-isobutyl-isoxazol-5-ylamine (1057064-36-4)

Guidance literature:

upstream raw materials:

5-isobutyl-isoxazole

5-methyl-3-oxo-hexanenitrile

Refernces

• 1、 -. "Pyridyloxyindoles Inhibitors of VEGF-R2 and Use Thereof for Treatment of Disease". Page/Page column 59. . Retrieved 2010/06/22.