(2R,6S,7R,9S,10S)-10-Hydroxy-5-[(2E,6E)-(R)-8-((2R,4S,6R,8R,9S)-4-hydroxy-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl)-4,6-dimethyl-octa-2,6-dien-(E)-ylidene]-9-methyl-2-phenyl-1,3-dioxa-spiro[5.5]undecane-7-carboxylic acid

Base Information

Chemical Name:(2R,6S,7R,9S,10S)-10-Hydroxy-5-[(2E,6E)-(R)-8-((2R,4S,6R,8R,9S)-4-hydroxy-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl)-4,6-dimethyl-octa-2,6-dien-(E)-ylidene]-9-methyl-2-phenyl-1,3-dioxa-spiro[5.5]undecane-7-carboxylic acid
CAS No.:124553-39-5
Molecular Formula:C₃₈H₅₄O₈
Molecular Weight:638.842
Hs Code.:

(2R,6S,7R,9S,10S)-10-Hydroxy-5-[(2E,6E)-(R)-8-((2R,4S,6R,8R,9S)-4-hydroxy-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl)-4,6-dimethyl-octa-2,6-dien-(E)-ylidene]-9-methyl-2-phenyl-1,3-dioxa-spiro[5.5]undecane-7-carboxylic acid

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Suppliers and Price of (2R,6S,7R,9S,10S)-10-Hydroxy-5-[(2E,6E)-(R)-8-((2R,4S,6R,8R,9S)-4-hydroxy-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl)-4,6-dimethyl-octa-2,6-dien-(E)-ylidene]-9-methyl-2-phenyl-1,3-dioxa-spiro[5.5]undecane-7-carboxylic acid

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Chemical Property of (2R,6S,7R,9S,10S)-10-Hydroxy-5-[(2E,6E)-(R)-8-((2R,4S,6R,8R,9S)-4-hydroxy-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl)-4,6-dimethyl-octa-2,6-dien-(E)-ylidene]-9-methyl-2-phenyl-1,3-dioxa-spiro[5.5]undecane-7-carboxylic acid

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Technology Process of (2R,6S,7R,9S,10S)-10-Hydroxy-5-[(2E,6E)-(R)-8-((2R,4S,6R,8R,9S)-4-hydroxy-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl)-4,6-dimethyl-octa-2,6-dien-(E)-ylidene]-9-methyl-2-phenyl-1,3-dioxa-spiro[5.5]undecane-7-carboxylic acid

There total 25 articles about (2R,6S,7R,9S,10S)-10-Hydroxy-5-[(2E,6E)-(R)-8-((2R,4S,6R,8R,9S)-4-hydroxy-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl)-4,6-dimethyl-octa-2,6-dien-(E)-ylidene]-9-methyl-2-phenyl-1,3-dioxa-spiro[5.5]undecane-7-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 115031-05-5
(+)-<2R,4E,6(2R,4S,6S,8R,9S)>-6-(4-benzoyloxy-8,9-dimethyl-1,7-dioxaspiro<5.5>undecan-2-yl)-2,4-dimethyl-4-hexenal

: 124553-39-5
(2R,6S,7R,9S,10S)-10-Hydroxy-5-[(2E,6E)-(R)-8-((2R,4S,6R,8R,9S)-4-hydroxy-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl)-4,6-dimethyl-octa-2,6-dien-(E)-ylidene]-9-methyl-2-phenyl-1,3-dioxa-spiro[5.5]undecane-7-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 83 percent / t-butyl lithium / tetrahydrofuran / -78 °C

2: sodium amalgam, Na₂HPO₄ / tetrahydrofuran; methanol / -40 °C

3: 27 percent / py, DMAP

4: 91 percent / TBAF / tetrahydrofuran / Heating

5: 76 percent / tetra-n-propylammonium perruthenate, NMO, 4 angstroem ground sieves / CH₂Cl₂

6: sodium chlorite, 2-methyl-2-butene, KH₂PO₄ / 2-methyl-propan-2-ol; H₂O

7: sodium methoxide / methanol

With pyridine; dmap; sodium chlorite; disodium hydrogenphosphate; potassium dihydrogenphosphate; sodium amalgam; N-methyl-2-indolinone; tetrapropylammonium perruthennate; 2-methyl-but-2-ene; 4 A molecular sieve; tetrabutyl ammonium fluoride; tert.-butyl lithium; sodium methylate; In tetrahydrofuran; methanol; dichloromethane; water; tert-butyl alcohol;
DOI:10.1016/S0040-4039(00)99203-7

Reference yield:

: 127785-60-8
(+)-<2R,5E<2E,4R,6E,8(2R,4S,6S,8R,9S)>,6S,8S,9S,11S>-10-benzoyloxy-5-<(4-benzoyloxy-8,9-dimethyl-1,7-dioxaspiro<5.5>undecan-2-yl)-4,6-dimethyl-2,6-octadienylidene>-9-methyl-2-phenyl-1,3-dioxaspiro<5.5>undecane-7-methanol

: 124553-39-5
(2R,6S,7R,9S,10S)-10-Hydroxy-5-[(2E,6E)-(R)-8-((2R,4S,6R,8R,9S)-4-hydroxy-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl)-4,6-dimethyl-octa-2,6-dien-(E)-ylidene]-9-methyl-2-phenyl-1,3-dioxa-spiro[5.5]undecane-7-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / tetra-n-propylammonium perruthenate, NMO, 4 angstroem ground sieves / CH₂Cl₂

2: sodium chlorite, 2-methyl-2-butene, KH₂PO₄ / 2-methyl-propan-2-ol; H₂O

3: sodium methoxide / methanol

With sodium chlorite; potassium dihydrogenphosphate; N-methyl-2-indolinone; tetrapropylammonium perruthennate; 2-methyl-but-2-ene; 4 A molecular sieve; sodium methylate; In methanol; dichloromethane; water; tert-butyl alcohol;
DOI:10.1016/S0040-4039(00)99203-7

Reference yield:

: 124553-37-3
(+)-<2R,5E<2E,4R,6E,8(2R,4S,6S,8R,9S)>,6S,8S,9S,11S>-5-<(4-benzoyloxy-8,9-dimethyl-1,7-dioxaspiro<5.5>undecan-2-yl)-4,6-dimethyl-2,6-octadienylidene>-11-<(tert-butyldiphenylsilyloxy)methyl>-9-methyl-2-phenyl-1,3-dioxaspiro<5.5>undecan-8-ol

: 124553-39-5
(2R,6S,7R,9S,10S)-10-Hydroxy-5-[(2E,6E)-(R)-8-((2R,4S,6R,8R,9S)-4-hydroxy-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl)-4,6-dimethyl-octa-2,6-dien-(E)-ylidene]-9-methyl-2-phenyl-1,3-dioxa-spiro[5.5]undecane-7-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / TBAF / tetrahydrofuran / Heating

2: 76 percent / tetra-n-propylammonium perruthenate, NMO, 4 angstroem ground sieves / CH₂Cl₂

3: sodium chlorite, 2-methyl-2-butene, KH₂PO₄ / 2-methyl-propan-2-ol; H₂O

4: sodium methoxide / methanol

With sodium chlorite; potassium dihydrogenphosphate; N-methyl-2-indolinone; tetrapropylammonium perruthennate; 2-methyl-but-2-ene; 4 A molecular sieve; tetrabutyl ammonium fluoride; sodium methylate; In tetrahydrofuran; methanol; dichloromethane; water; tert-butyl alcohol;
DOI:10.1016/S0040-4039(00)99203-7