Deterenol hydrochloride, (R)-

Base Information

• Chemical Name: Deterenol hydrochloride, (R)-
• CAS No.: 1291099-44-9
• Molecular Formula: C₁₁H₁₇NO₂*ClH
• Molecular Weight: 231.722
• UNII: NIZ21G3DCF
• Mol file: 1291099-44-9.mol

Synonyms:NIZ21G3DCF;Deterenol hydrochloride, (R)-;UNII-NIZ21G3DCF;1291099-44-9;Benzenemethanol, 4-hydroxy-alpha-(((1-methylethyl)amino)methyl)-, hydrochloride (1:1), (alphaR)-;BENZENEMETHANOL, 4-HYDROXY-.ALPHA.-(((1-METHYLETHYL)AMINO)METHYL)-, HYDROCHLORIDE (1:1), (.ALPHA.R)-

Chemical Property of Deterenol hydrochloride, (R)-

Chemical Property:

• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 231.1026065
• Heavy Atom Count: 15
• Complexity: 153

Purity/Quality:

95%+ or 98%+ ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C)NCC(C1=CC=C(C=C1)O)O.Cl
• Isomeric SMILES: CC(C)NC[C@@H](C1=CC=C(C=C1)O)O.Cl

Technology Process of Deterenol hydrochloride, (R)-

There total 5 articles about Deterenol hydrochloride, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C13H17NO6 (1291099-39-2) → (R)-N-isopropylnorsynephrine hydrochloride (1291099-44-9)

Guidance literature:

Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 22 h

2: magnesium sulfate / ethanol / 20 °C / Inert atmosphere

3: sodium tetrahydroborate / 1 h / 0 °C / Inert atmosphere

4: methanol; acetyl chloride / 6 h / 20 °C / Inert atmosphere

With methanol; sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; magnesium sulfate; acetyl chloride; In ethanol;

DOI:10.1021/jo200318b

Reference yield:

C13H19NO4 (1291099-42-7) → (R)-N-isopropylnorsynephrine hydrochloride (1291099-44-9)

Guidance literature:

Multi-step reaction with 3 steps

1: magnesium sulfate / ethanol / 20 °C / Inert atmosphere

2: sodium tetrahydroborate / 1 h / 0 °C / Inert atmosphere

3: methanol; acetyl chloride / 6 h / 20 °C / Inert atmosphere

With methanol; sodium tetrahydroborate; magnesium sulfate; acetyl chloride; In ethanol;

DOI:10.1021/jo200318b

Reference yield:

C16H25NO4 (1291099-43-8) → (R)-N-isopropylnorsynephrine hydrochloride (1291099-44-9)

Guidance literature:

With methanol; acetyl chloride; at 20 ℃; for 6h; Inert atmosphere;

DOI:10.1021/jo200318b

upstream raw materials:

C₁₃H₁₇NO₆

C₁₃H₁₉NO₄

C₁₆H₂₅NO₄

para-tert-butoxycarbonyloxybenzaldehyde