Technology Process of 5-chloro-6-(m-tolyl)benzo[b]naphtho[2,1-d]thiophene
There total 5 articles about 5-chloro-6-(m-tolyl)benzo[b]naphtho[2,1-d]thiophene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
copper dichloride; palladium dichloride;
In
tetrahydrofuran;
for 24h;
Reflux;
DOI:10.1021/jo500377v
- Guidance literature:
-
Multi-step reaction with 4 steps
1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C
2: tetrakis(triphenylphosphine) palladium(0); copper(l) iodide; N-butylamine / diethyl ether / 6 h / 20 °C
3: tetrakis(triphenylphosphine) palladium(0); copper(l) iodide; N-butylamine / diethyl ether / 6 h / 20 °C
4: copper dichloride; palladium dichloride / tetrahydrofuran / 24 h / Reflux
With
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); tetrabutyl ammonium fluoride; N-butylamine; copper dichloride; palladium dichloride;
In
tetrahydrofuran; diethyl ether;
2: |Sonogashira Cross-Coupling / 3: |Sonogashira Cross-Coupling;
DOI:10.1021/jo500377v
- Guidance literature:
-
Multi-step reaction with 3 steps
1: tetrakis(triphenylphosphine) palladium(0); copper(l) iodide; N-butylamine / diethyl ether / 6 h / 20 °C
2: tetrakis(triphenylphosphine) palladium(0); copper(l) iodide; N-butylamine / diethyl ether / 6 h / 20 °C
3: copper dichloride; palladium dichloride / tetrahydrofuran / 24 h / Reflux
With
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); N-butylamine; copper dichloride; palladium dichloride;
In
tetrahydrofuran; diethyl ether;
1: |Sonogashira Cross-Coupling / 2: |Sonogashira Cross-Coupling;
DOI:10.1021/jo500377v
