2-{4-[(1-{6-[(3R)-3-{[2-(4-cyanophenyl)ethyl]carbamoyl}piperidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl}piperidin-4-yl)oxy]phenyl}acetic acid

Base Information

Chemical Name:2-{4-[(1-{6-[(3R)-3-{[2-(4-cyanophenyl)ethyl]carbamoyl}piperidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl}piperidin-4-yl)oxy]phenyl}acetic acid
CAS No.:1595145-19-9
Molecular Formula:C₃₃H₃₅F₃N₆O₄
Molecular Weight:636.674
Hs Code.:

2-{4-[(1-{6-[(3R)-3-{[2-(4-cyanophenyl)ethyl]carbamoyl}piperidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl}piperidin-4-yl)oxy]phenyl}acetic acid

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Chemical Property of 2-{4-[(1-{6-[(3R)-3-{[2-(4-cyanophenyl)ethyl]carbamoyl}piperidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl}piperidin-4-yl)oxy]phenyl}acetic acid

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Technology Process of 2-{4-[(1-{6-[(3R)-3-{[2-(4-cyanophenyl)ethyl]carbamoyl}piperidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl}piperidin-4-yl)oxy]phenyl}acetic acid

There total 11 articles about 2-{4-[(1-{6-[(3R)-3-{[2-(4-cyanophenyl)ethyl]carbamoyl}piperidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl}piperidin-4-yl)oxy]phenyl}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₄H₃₇F₃N₆O₄

: 1595145-19-9
2-{4-[(1-{6-[(3R)-3-{[2-(4-cyanophenyl)ethyl]carbamoyl}piperidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl}piperidin-4-yl)oxy]phenyl}acetic acid

Guidance literature:: C₃₄H₃₇F₃N₆O₄; With lithium hydroxide; In tetrahydrofuran; ethanol; at 25 ℃;

With hydrogenchloride; In tetrahydrofuran; ethanol; pH=3;
DOI:10.1021/jm401731q

Reference yield:

: 1595144-08-3
(R)-tert-butyl 3-((4-cyanophenylethyl)carbamoyl)piperidine-1-carboxylate

: 1595145-19-9
2-{4-[(1-{6-[(3R)-3-{[2-(4-cyanophenyl)ethyl]carbamoyl}piperidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl}piperidin-4-yl)oxy]phenyl}acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / ethyl acetate; 1,4-dioxane / 0 °C

1.2: pH 12

2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.5 h / 0 - 25 °C

3.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 20 h / 130 °C / Sealed tube

4.1: lithium hydroxide / tetrahydrofuran; ethanol / 25 °C

4.2: pH 3

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; ethyl acetate; isopropyl alcohol; acetonitrile;
DOI:10.1021/jm401731q

Reference yield:

: 1595144-10-7
C₁₅H₁₉N₃O*ClH

: 1595145-19-9
2-{4-[(1-{6-[(3R)-3-{[2-(4-cyanophenyl)ethyl]carbamoyl}piperidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl}piperidin-4-yl)oxy]phenyl}acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 0.25 h / 0 - 25 °C

2.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 20 h / 130 °C / Sealed tube

3.1: lithium hydroxide / tetrahydrofuran; ethanol / 25 °C

3.2: pH 3

With N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; ethanol; isopropyl alcohol;
DOI:10.1021/jm401731q