Technology Process of 5-<4-(5-chloro-2-methoxybenzoylamino)benzyl>thiazolidine-2,4-dione
There total 4 articles about 5-<4-(5-chloro-2-methoxybenzoylamino)benzyl>thiazolidine-2,4-dione which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 2.) 2N HCl / 1.) sulfolane, 120 deg C, 5 h; 2.) sulfolane, 100 deg C, 15 h
2: 88.6 percent / hydrogen / 10percent Pd-C / methanol; ethyl acetate / 760 Torr / Ambient temperature
3: 1.) thionyl chloride / 1.) C6H6, reflux, 1h; 2.) DMF, room temp., 30 min
With
hydrogenchloride; thionyl chloride; hydrogen;
palladium on activated charcoal;
In
methanol; ethyl acetate;
DOI:10.1248/cpb.30.3580
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) NaNO2, conc. HCl, 2.) Cu2O / 1.) acetone, water, 5 deg C, 30 min, 2.) acetone, water, 10 deg C
2: 2.) 2N HCl / 1.) sulfolane, 120 deg C, 5 h; 2.) sulfolane, 100 deg C, 15 h
3: 88.6 percent / hydrogen / 10percent Pd-C / methanol; ethyl acetate / 760 Torr / Ambient temperature
4: 1.) thionyl chloride / 1.) C6H6, reflux, 1h; 2.) DMF, room temp., 30 min
With
copper(I) oxide; hydrogenchloride; thionyl chloride; hydrogen; sodium nitrite;
palladium on activated charcoal;
In
methanol; ethyl acetate;
DOI:10.1248/cpb.30.3580
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 88.6 percent / hydrogen / 10percent Pd-C / methanol; ethyl acetate / 760 Torr / Ambient temperature
2: 1.) thionyl chloride / 1.) C6H6, reflux, 1h; 2.) DMF, room temp., 30 min
With
thionyl chloride; hydrogen;
palladium on activated charcoal;
In
methanol; ethyl acetate;
DOI:10.1248/cpb.30.3580
