DL-Phenylalanine, N-[(phenylmethoxy)carbonyl]-a-(trifluoromethyl)-

Base Information

• Chemical Name: DL-Phenylalanine, N-[(phenylmethoxy)carbonyl]-a-(trifluoromethyl)-
• CAS No.: 139520-45-9
• Molecular Formula: C18H16F3NO4
• Molecular Weight: 367.31900
• Hs Code.: 2922498590
• Mol file: 139520-45-9.mol

Synonyms:2-Benzyl-2-benzyloxycarbonylamino-3,3,3-trifluoro-propionic acid;

Chemical Property of DL-Phenylalanine, N-[(phenylmethoxy)carbonyl]-a-(trifluoromethyl)-

Chemical Property:

• PSA: 75.63000
• LogP: 3.93210

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DL-Phenylalanine, N-[(phenylmethoxy)carbonyl]-a-(trifluoromethyl)-

There total 1 articles about DL-Phenylalanine, N-[(phenylmethoxy)carbonyl]-a-(trifluoromethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.0%

Z-TFM-Phe-OMe → N-(benzyloxycarbonyl)-α-(trifluoromethyl)phenylalanine (139520-45-9)

Guidance literature:

With phosphatbuffer; In N,N-dimethyl-formamide; at 30 ℃;

DOI:10.1002/prac.19933350404

Reference yield: 88.0%

N-(benzyloxycarbonyl)-α-(trifluoromethyl)phenylalanine (139520-45-9) → 2-Benzyloxy-4-benzyl-4-trifluormethyl-5(4H)-oxazolon (152604-26-7)

Guidance literature:

With dicyclohexyl-carbodiimide; In dichloromethane; Ambient temperature;

DOI:10.1002/prac.19933350404

Reference yield: 34.0%

N-(benzyloxycarbonyl)-α-(trifluoromethyl)phenylalanine (139520-45-9) → 4-Benzyl-4-trifluoromethyl-oxazolidine-2,5-dione (139520-49-3)

Guidance literature:

With thionyl chloride; at 80 ℃;

DOI:10.1016/0040-4039(92)88047-9

Downstream raw materials:

4-Benzyl-4-trifluoromethyl-oxazolidine-2,5-dione

2-Benzyloxy-4-benzyl-4-trifluormethyl-5(4H)-oxazolon

4-[N',N''-bis(tert-butyloxycarbonyl)guanidino]phenyl N-(benzyloxycarbonyl)-α-(trifluoromethyl)-D,L-phenylalaninate

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