N'-(S)-[1-(1-naphthyl)ethyl]-N-(S)-3-[4-(trifluoromethyl)phenoxy]-3-phenylpropylurea

Base Information

• Chemical Name: N'-(S)-[1-(1-naphthyl)ethyl]-N-(S)-3-[4-(trifluoromethyl)phenoxy]-3-phenylpropylurea
• CAS No.: 878663-17-3
• Molecular Formula: C₂₉H₂₇F₃N₂O₂
• Molecular Weight: 492.541

Synonyms:

Chemical Property of N'-(S)-[1-(1-naphthyl)ethyl]-N-(S)-3-[4-(trifluoromethyl)phenoxy]-3-phenylpropylurea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N'-(S)-[1-(1-naphthyl)ethyl]-N-(S)-3-[4-(trifluoromethyl)phenoxy]-3-phenylpropylurea

There total 4 articles about N'-(S)-[1-(1-naphthyl)ethyl]-N-(S)-3-[4-(trifluoromethyl)phenoxy]-3-phenylpropylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-hydroxybenzotrifluoride (402-45-9) → N'-(S)-[1-(1-naphthyl)ethyl]-N-(S)-3-[4-(trifluoromethyl)phenoxy]-3-phenylpropylurea (878663-17-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: sodium iodide / dimethyl sulfoxide / 13 h / 70 °C

3.1: hydrazine hydrate / methanol; dichloromethane / 8 h / 20 °C

4.1: toluene / 13 h / 20 °C

With di-isopropyl azodicarboxylate; hydrazine hydrate; triphenylphosphine; sodium iodide; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; toluene; 1.1: Mitsunobu reaction / 1.2: Mitsunobu reaction;

DOI:10.1016/j.bmc.2008.10.065

Reference yield:

(S)-1-phthalimido-3-(4-trifluormethyl-phenoxy)-3-phenyl-propane (878663-13-9) → N'-(S)-[1-(1-naphthyl)ethyl]-N-(S)-3-[4-(trifluoromethyl)phenoxy]-3-phenylpropylurea (878663-17-3)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / methanol; dichloromethane / 8 h / 20 °C

2: toluene / 13 h / 20 °C

With hydrazine hydrate; In methanol; dichloromethane; toluene;

DOI:10.1016/j.bmc.2008.10.065

Reference yield:

-(-)-1-chloro-3-phenyl-3-<4-(trifluoromethyl)phenoxy>propane (114446-51-4) → N'-(S)-[1-(1-naphthyl)ethyl]-N-(S)-3-[4-(trifluoromethyl)phenoxy]-3-phenylpropylurea (878663-17-3)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium iodide / dimethyl sulfoxide / 13 h / 70 °C

2: hydrazine hydrate / methanol; dichloromethane / 8 h / 20 °C

3: toluene / 13 h / 20 °C

With hydrazine hydrate; sodium iodide; In methanol; dichloromethane; dimethyl sulfoxide; toluene;

DOI:10.1016/j.bmc.2008.10.065

upstream raw materials:

(S)-1-phthalimido-3-(4-trifluormethyl-phenoxy)-3-phenyl-propane

4-hydroxybenzotrifluoride

(1R)-3-chloro-1-phenylpropanol

-(-)-1-chloro-3-phenyl-3-<4-(trifluoromethyl)phenoxy>propane

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 878663-17-3 N'-(S)-[1-(1-naphthyl)ethyl]-N-(S)-3-[4-(trifluoromethyl)phenoxy]-3-phenylpropylurea

Send

Send

Metric Ton KG G Pound L ML

Send

Send