(1R,4aR,8aS)-decahydronaphthalen-1-ol

Base Information

• Chemical Name: (1R,4aR,8aS)-decahydronaphthalen-1-ol
• CAS No.: 821788-48-1
• Molecular Formula: C₁₀H₁₈O
• Molecular Weight: 154.252
• Mol file: 821788-48-1.mol

Synonyms:

Chemical Property of (1R,4aR,8aS)-decahydronaphthalen-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,4aR,8aS)-decahydronaphthalen-1-ol

There total 11 articles about (1R,4aR,8aS)-decahydronaphthalen-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

(1R,8aS)-1,2,3,4,5,6,7,8,8a-octahydronaphthalen-1-ol (821788-47-0) → (1R,4aR,8aS)-decahydronaphthalen-1-ol (821788-48-1,207127-50-2,691892-12-3) + 1t.9c.10t-α-Dekalol (54422-08-1,207127-50-2,691892-12-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In diethyl ether; at 20 ℃; for 2h; under 2844.31 Torr;

DOI:10.1016/j.tetasy.2004.10.004

Reference yield:

1α,4α-dihydroxy-cis-1,2,3,4,4a,5,8,8a-octahydronaphthalene (63950-11-8) → (1R,4aR,8aS)-decahydronaphthalen-1-ol (821788-48-1,207127-50-2,691892-12-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 85 percent / Candida antarctica lipase B / 40 °C

2: hydrogen / palladium on carbon / ethyl acetate / 4 h / 2068.59 Torr

3: 91 percent / triethylamine / CH₂Cl₂ / 0 - 20 °C

4: 88 percent / LiAlH₄ / tetrahydrofuran / 4 h / 20 °C

5: 62 percent / hydrogen / palladium on carbon / diethyl ether / 2 h / 20 °C / 2844.31 Torr

With Candida antarctica lipase B; lithium aluminium tetrahydride; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate;

DOI:10.1016/j.tetasy.2004.10.004

Reference yield:

(1R,4S,4aR,8aS)-4-(acetoxy)-1,2,3,4,4a,5,8,8a-octahydronaphthalen-1-yl acetate (85737-81-1,115333-86-3) → (1R,4aR,8aS)-decahydronaphthalen-1-ol (821788-48-1,207127-50-2,691892-12-3)

Guidance literature:

Multi-step reaction with 6 steps

1: pig liver esterase; phosphate buffer / 38 °C / pH 7

2: 85 percent / Candida antarctica lipase B / 40 °C

3: hydrogen / palladium on carbon / ethyl acetate / 4 h / 2068.59 Torr

4: 91 percent / triethylamine / CH₂Cl₂ / 0 - 20 °C

5: 88 percent / LiAlH₄ / tetrahydrofuran / 4 h / 20 °C

6: 62 percent / hydrogen / palladium on carbon / diethyl ether / 2 h / 20 °C / 2844.31 Torr

With Candida antarctica lipase B; lithium aluminium tetrahydride; phosphate buffer; pig liver esterase; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate;

DOI:10.1016/j.tetasy.2004.10.004

upstream raw materials:

cis-1,2-epoxy-cyclodecane

(1R,8aS)-1,2,3,4,5,6,7,8,8a-octahydronaphthalen-1-ol

1α,4α-dihydroxy-cis-1,2,3,4,4a,5,8,8a-octahydronaphthalene

(1R,4S,4aR,8aS)-decahydronaphthalene-1,4-diol