cis-6-methylpipecolinic acid

Base Information

• Chemical Name: cis-6-methylpipecolinic acid
• CAS No.: 89460-67-3
• Molecular Formula: C₇H₁₃NO₂
• Molecular Weight: 143.186
• Mol file: 89460-67-3.mol

Synonyms:

Chemical Property of cis-6-methylpipecolinic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cis-6-methylpipecolinic acid

There total 3 articles about cis-6-methylpipecolinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

6-methylpyridine-2-carboxylic acid hydrochlorid salt (87884-49-9) → cis-6-methylpipecolinic acid (89115-89-9,89163-80-4,89460-67-3,99571-58-1)

Guidance literature:

With hydrogen; platinum(IV) oxide; In ethanol; water; at 60 ℃; for 24h; under 3102.9 Torr;

DOI:10.1021/jo00289a058

Reference yield:

2-methylpyridine N-oxide (931-19-1) → cis-6-methylpipecolinic acid (89115-89-9,89163-80-4,89460-67-3,99571-58-1)

Guidance literature:

Multi-step reaction with 3 steps

1: dimethylcarbamyl chloride / CH₂Cl₂ / 24 h / Ambient temperature

2: 96 percent / 6 N HCl / 24 h / Heating

3: 87 percent / hydrogen / platinum oxide / ethanol; H₂O / 24 h / 60 °C / 3102.9 Torr

With hydrogenchloride; hydrogen; N,N-Dimethylcarbamoyl chloride; platinum(IV) oxide; In ethanol; dichloromethane; water;

DOI:10.1021/jo00289a058

Reference yield:

2-Cyano-6-methylpyridine (1620-75-3) → cis-6-methylpipecolinic acid (89115-89-9,89163-80-4,89460-67-3,99571-58-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / 6 N HCl / 24 h / Heating

2: 87 percent / hydrogen / platinum oxide / ethanol; H₂O / 24 h / 60 °C / 3102.9 Torr

With hydrogenchloride; hydrogen; platinum(IV) oxide; In ethanol; water;

DOI:10.1021/jo00289a058

upstream raw materials:

6-methylpyridine-2-carboxylic acid hydrochlorid salt

2-methylpyridine N-oxide

2-Cyano-6-methylpyridine

Downstream raw materials:

cis-6-methylpipecolinic 2,6-dimethylanilide

n-butyl cis-6-methylpipecolinate