(1'S,3S)-diethyl-1-benzyl-5-chloro-1'-(4-nitrophenyl)-2-oxo-1',2'-dihydrospiro[indoline-3,4'-pyrido[3,4-b]indole]-3',3'(9'H)-dicarboxylate

Base Information

• Chemical Name: (1'S,3S)-diethyl-1-benzyl-5-chloro-1'-(4-nitrophenyl)-2-oxo-1',2'-dihydrospiro[indoline-3,4'-pyrido[3,4-b]indole]-3',3'(9'H)-dicarboxylate
• CAS No.: 1609976-06-8
• Molecular Formula: C₃₇H₃₁ClN₄O₇
• Molecular Weight: 679.129
• Mol file: 1609976-06-8.mol

Synonyms:

Chemical Property of (1'S,3S)-diethyl-1-benzyl-5-chloro-1'-(4-nitrophenyl)-2-oxo-1',2'-dihydrospiro[indoline-3,4'-pyrido[3,4-b]indole]-3',3'(9'H)-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1'S,3S)-diethyl-1-benzyl-5-chloro-1'-(4-nitrophenyl)-2-oxo-1',2'-dihydrospiro[indoline-3,4'-pyrido[3,4-b]indole]-3',3'(9'H)-dicarboxylate

There total 1 articles about (1'S,3S)-diethyl-1-benzyl-5-chloro-1'-(4-nitrophenyl)-2-oxo-1',2'-dihydrospiro[indoline-3,4'-pyrido[3,4-b]indole]-3',3'(9'H)-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

aminomalonic acid diethyl ester (6829-40-9) + 1-benzyl-5-chloro-3-hydroxy-3-(1H-indol-3-yl)indolin-2-one (676612-51-4) + 4-nitrobenzaldehdye (555-16-8) → (1'S,3S)-diethyl-1-benzyl-5-chloro-1'-(4-nitrophenyl)-2-oxo-1',2'-dihydrospiro[indoline-3,4'-pyrido[3,4-b]indole]-3',3'(9'H)-dicarboxylate (1609976-06-8) + diethyl-1-benzyl-5-chloro-1'-(4-nitrophenyl)-2-oxo-1',2'-dihydrospiro[indoline-3,4'-pyrido[3,4-b]indole]-3',3'(9'H)-dicarboxylate

Guidance literature:

With (R)‐3,3′‐bis(9‐phenanthryl)‐1,1′‐binaphthalene‐2,2′‐diyl hydrogen phosphate; In 1,2-dichloro-ethane; at 30 ℃; for 24h; Overall yield = 42 %; enantioselective reaction; Molecular sieve;

DOI:10.1002/chem.201304187

upstream raw materials:

aminomalonic acid diethyl ester

1-benzyl-5-chloro-3-hydroxy-3-(1H-indol-3-yl)indolin-2-one

4-nitrobenzaldehdye