Technology Process of 3-(4-Chloro-phenyl)-2-(4-methoxy-phenylamino)-7-methyl-3H-1,3,4-triaza-phenalene-5-carboxylic acid ethyl ester
There total 7 articles about 3-(4-Chloro-phenyl)-2-(4-methoxy-phenylamino)-7-methyl-3H-1,3,4-triaza-phenalene-5-carboxylic acid ethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: H2 / 10percent Pd/C
2: LiAlH4
3: 2) sodium azide
4: pyridinium chlorochromate
6: triphenylphosphine
7: CH2Cl2 / 5 h / Ambient temperature; other heterocumulenes
8: toluene / 1) r.t., 30 min, 2) 170 deg C, 24 h
With
lithium aluminium tetrahydride; sodium azide; hydrogen; triphenylphosphine; pyridinium chlorochromate;
palladium on activated charcoal;
In
dichloromethane; toluene;
DOI:10.1016/S0040-4039(00)92391-8
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1) H2SO4, NaNO2, 2) NaN3 / 1) H2O, 0 deg C, 30 min, 2) 3 h
2: pyridinium chlorochromate / CH2Cl2 / 4 h / Ambient temperature
3: 67 percent / Na, EtOH / 5 h / -15 °C
4: 91 percent / diethyl ether / 12 h / Ambient temperature
5: 83 percent / CH2Cl2 / Ambient temperature; 1 equiv of isocyanate (reaction with 2 equiv of isocyanate, toluene, r.t., 1 h, then 160 deg, 1h leads directly to pyrido<2,3,4-de>quinazolines); sequential treatment with isocyanate and ketene or aldehydes and isocyanates; reaction with CS2
6: toluene / 1) room temperature, 1 h, 2) 160 deg C, 24 h
With
sodium azide; ethanol; sulfuric acid; sodium; pyridinium chlorochromate; sodium nitrite;
In
diethyl ether; dichloromethane; toluene;
DOI:10.1021/jo00051a007
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 67 percent / Na, EtOH / 5 h / -15 °C
2: 91 percent / diethyl ether / 12 h / Ambient temperature
3: 83 percent / CH2Cl2 / Ambient temperature; 1 equiv of isocyanate (reaction with 2 equiv of isocyanate, toluene, r.t., 1 h, then 160 deg, 1h leads directly to pyrido<2,3,4-de>quinazolines); sequential treatment with isocyanate and ketene or aldehydes and isocyanates; reaction with CS2
4: toluene / 1) room temperature, 1 h, 2) 160 deg C, 24 h
With
ethanol; sodium;
In
diethyl ether; dichloromethane; toluene;
DOI:10.1021/jo00051a007
