C₂₃H₂₉N₅O₄

Base Information

• Chemical Name: C₂₃H₂₉N₅O₄
• CAS No.: 1351533-46-4
• Molecular Formula: C₂₃H₂₉N₅O₄
• Molecular Weight: 439.514
• Mol file: 1351533-46-4.mol

Synonyms:

Chemical Property of C₂₃H₂₉N₅O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₃H₂₉N₅O₄

There total 5 articles about C₂₃H₂₉N₅O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl (4-(5-(3-(hydroxymethyl)phenyl)-7-((2-(trimethylsilyl)-ethoxy)-methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)morpholin-2-yl)methyl-carbamate (1351533-44-2) → C23H29N5O4 (1351533-46-4)

Guidance literature:

With tetrabutyl ammonium fluoride; ethylenediamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 60 ℃; Inert atmosphere;

DOI:10.1021/jm2007326

Reference yield:

5-bromo-4-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine (1034769-73-7) → C23H29N5O4 (1351533-46-4)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / butan-1-ol / 1 h / 100 °C / Inert atmosphere; Microwave irradiation

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 0.5 h / 120 °C / Inert atmosphere; Microwave irradiation

3: tetrabutyl ammonium fluoride; ethylenediamine / tetrahydrofuran; N,N-dimethyl-formamide / 60 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; sodium carbonate; ethylenediamine; triethylamine; In tetrahydrofuran; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; butan-1-ol; 2: Suzuki coupling;

DOI:10.1021/jm2007326

Reference yield:

tert-butyl (4-(5-bromo-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)morpholin-2-yl)methylcarbamate (1034769-74-8) → C23H29N5O4 (1351533-46-4)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 0.5 h / 120 °C / Inert atmosphere; Microwave irradiation

2: tetrabutyl ammonium fluoride; ethylenediamine / tetrahydrofuran; N,N-dimethyl-formamide / 60 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; sodium carbonate; ethylenediamine; In tetrahydrofuran; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; 1: Suzuki coupling;

DOI:10.1021/jm2007326

upstream raw materials:

tert-butyl (4-(5-(3-(hydroxymethyl)phenyl)-7-((2-(trimethylsilyl)-ethoxy)-methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)morpholin-2-yl)methyl-carbamate

5-bromo-4-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine

tert-butyl (4-(5-bromo-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)morpholin-2-yl)methylcarbamate

5-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

Downstream raw materials:

(3-(4-(2-(aminomethyl)morpholino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl)methanol