4-[(4-METHYLPIPERIDIN-1-YL)SULFONYL]BENZOIC ACID

Base Information

• Chemical Name: 4-[(4-METHYLPIPERIDIN-1-YL)SULFONYL]BENZOIC ACID
• CAS No.: 385381-42-0
• Molecular Formula: C₁₃H₁₇NO₄S
• Molecular Weight: 283.348
• Mol file: 385381-42-0.mol

Synonyms:

Chemical Property of 4-[(4-METHYLPIPERIDIN-1-YL)SULFONYL]BENZOIC ACID

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

4-(4-Methyl-piperidine-1-sulfonyl)-benzoic acid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of 4-[(4-METHYLPIPERIDIN-1-YL)SULFONYL]BENZOIC ACID

There total 4 articles about 4-[(4-METHYLPIPERIDIN-1-YL)SULFONYL]BENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

4-(4-methylpiperidine-1-sulfonyl)benzoic acid ethyl ester → 4-(4-methylpiperidine-1-sulfonyl)benzoic acid (385381-42-0)

Guidance literature:

With lithium hydroxide monohydrate; In methanol; water; at 20 ℃; for 2h;

DOI:10.1016/j.ejmech.2022.114145

Reference yield: 83.6%

→ 4-(4-methylpiperidine-1-sulfonyl)benzoic acid (385381-42-0)

Guidance literature:

With water; sodium hydroxide; In N,N-dimethyl-formamide; at 80 ℃; for 4h;

Reference yield:

4-ethoxycarbonylbenzenesulfonyl chloride (10486-51-8) → 4-(4-methylpiperidine-1-sulfonyl)benzoic acid (385381-42-0)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 5 h / 20 °C / Inert atmosphere; Cooling with ice

2: lithium hydroxide monohydrate / methanol; water / 2 h / 20 °C

With lithium hydroxide monohydrate; triethylamine; In methanol; dichloromethane; water;

DOI:10.1016/j.ejmech.2022.114145

upstream raw materials:

4-ethoxycarbonylbenzenesulfonyl chloride

4-methylpiperidin