9-Amino-(9-deoxy)epi-quinine trihydrochloride

Base Information

• Chemical Name: 9-Amino-(9-deoxy)epi-quinine trihydrochloride
• CAS No.: 1231763-32-8
• Molecular Formula: C₂₀H₂₅N₃O*3ClH
• Molecular Weight: 432.821
• Hs Code.: 29339900
• Mol file: 1231763-32-8.mol

Synonyms:

Chemical Property of 9-Amino-(9-deoxy)epi-quinine trihydrochloride

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

(8α, 9S)-6'-Methoxycinchonan-9-amine trihydrochloride, min. 90% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

Useful:

Technology Process of 9-Amino-(9-deoxy)epi-quinine trihydrochloride

There total 9 articles about 9-Amino-(9-deoxy)epi-quinine trihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

Quinine (130-95-0) → (S)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methanamine hydrochloride (1231763-32-8,18797-90-5)

Guidance literature:

Quinine; With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

With diphenyl phosphoryl azide; In tetrahydrofuran; at 50 ℃; for 8h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water; Inert atmosphere;

DOI:10.1039/d1ob01306h

Reference yield: 84.0%

qunidine (56-54-2,130-95-0,572-59-8,572-60-1,42151-59-7,47342-58-5,72402-50-7,72402-51-8,72402-52-9,72402-53-0,101143-86-6,101143-87-7,101143-88-8,146925-10-2) → (S)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methanamine hydrochloride (1231763-32-8,18797-90-5)

Guidance literature:

qunidine; With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 ℃; for 0.166667h; Inert atmosphere;

With diphenyl phosphoryl azide; In tetrahydrofuran; at 20 - 45 ℃; for 8h; Inert atmosphere;

With hydrogenchloride; In dichloromethane; Inert atmosphere;

DOI:10.1021/jo401352z

Reference yield: 82.0%

quinine (130-95-0) → C20H25N3O*3ClH (1231763-32-8,18797-90-5)

Guidance literature:

quinine; With di-isopropyl azodicarboxylate; diphenylphosphoranyl azide; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 16h; Inert atmosphere;

With triphenylphosphine; In water; at 20 - 50 ℃; for 4h;

With hydrogenchloride; In dichloromethane; water;

DOI:10.1039/c8cc00609a

upstream raw materials:

qunidine

quinine

(8S,9S)-9-azido-(9-deoxy)epiquinine

Quinine

Downstream raw materials:

9-amino-9-deoxy-epihydroquinine

2-(diphenylphosphino)-N-((S)-((1S,2S,4S,5R)-5-ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methyl)benzamide

C₃₉H₃₈N₃O₂P