Methyl 5-thiazolecarboxylate

Base Information

• Chemical Name: Methyl 5-thiazolecarboxylate
• CAS No.: 14527-44-7
• Molecular Formula: C5H5NO2S
• Molecular Weight: 143.166
• Hs Code.: 2934100090
• Mol file: 14527-44-7.mol

Synonyms:5-Thiazolecarboxylic acid, methyl ester;NSC 321257;

Chemical Property of Methyl 5-thiazolecarboxylate

Chemical Property:

• Vapor Pressure: 0.117mmHg at 25°C
• Melting Point: 68-69 °C
• Refractive Index: 1.539
• Boiling Point: 219.8 °C at 760 mmHg
• PKA: 0.80±0.10(Predicted)
• Flash Point: 86.8 °C
• PSA: 67.43000
• Density: 1.301 g/cm³
• LogP: 0.92970
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

MethylThiazole-5-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:
• Hazard Codes: Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 5-thiazolecarboxylate

There total 5 articles about Methyl 5-thiazolecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

methyl 2-aminothiazole-5-carboxylate (6633-61-0) → methyl thiazole-5-carboxylate (14527-44-7)

Guidance literature:

With isopentyl nitrite; In tetrahydrofuran; at 120 ℃; for 0.333333h; Temperature; Solvent;

DOI:10.3390/molecules24101996

Reference yield:

methyl 2-aminothiazole-5-carboxylate (6633-61-0) + isopentyl nitrite (110-46-3) → methyl thiazole-5-carboxylate (14527-44-7)

Guidance literature:

In 1,4-dioxane; hexane; ethyl acetate;

Reference yield:

methyl 2-aminothiazole-5-carboxylate (6633-61-0) + n-Amyl nitrite (463-04-7) → methyl thiazole-5-carboxylate (14527-44-7)

Guidance literature:

In 1,4-dioxane;

upstream raw materials:

diazomethane

thiazole-5-carboxylic acid

methyl 2-chloro-3-oxopropionate

thiocarboxamide

Downstream raw materials:

methyl 2-(5-(4-methoxybenzyloxy)pyridin-2-yl)thiazole-5-carboxylate

methyl 2-acetylthiazole-5-carboxylate

thiazol-5-yl-methanol