Technology Process of benzyl (2S,3R)-2-(5-acetyl-1-oxo-2,5-diazaspiro[3.4]octan-2-yl)-3-(benzyloxy)butanoate
There total 9 articles about benzyl (2S,3R)-2-(5-acetyl-1-oxo-2,5-diazaspiro[3.4]octan-2-yl)-3-(benzyloxy)butanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: hydrogenchloride / methanol / 12 h / Inert atmosphere
2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C
3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 2 h / 20 °C
4: dichloromethane / 2 h / 0 - 20 °C
5: triethylamine / dichloromethane / 2 h / 0 - 20 °C
With
hydrogenchloride; di-isopropyl azodicarboxylate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine;
In
tetrahydrofuran; methanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C
2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 2 h / 20 °C
3: dichloromethane / 2 h / 0 - 20 °C
4: triethylamine / dichloromethane / 2 h / 0 - 20 °C
With
di-isopropyl azodicarboxylate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine;
In
tetrahydrofuran; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: thionyl chloride / 0 °C / Reflux
2.1: triethylamine / dichloromethane / 16 h / 0 - 20 °C
3.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C
3.2: 2 h / -78 - -20 °C
4.1: sodium hydroxide / water; methanol / 4 h / Reflux
5.1: hydrogen; palladium 10% on activated carbon / methanol / 24 h / 20 °C
6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C
7.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 2 h / 20 °C
8.1: dichloromethane / 2 h / 0 - 20 °C
9.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C
With
thionyl chloride; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; sodium hydroxide; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; dichloromethane; water;
