Technology Process of C24H23F3N2O3
There total 6 articles about C24H23F3N2O3 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-iodocyclohexanecarboxylic acid ethyl ester;
With
chloro-trimethyl-silane; ethylene dibromide; zinc;
In
tetrahydrofuran;
at 35 ℃;
for 1.5h;
8-(3-(trifluoromethoxy)phenyl)-1,7-naphthyridin-6-yl trifluoromethanesulfonate;
With
1,1'-bis-(diphenylphosphino)ferrocene; tetra-(n-butyl)ammonium iodide; bis(dibenzylideneacetone)-palladium(0);
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one;
at 35 ℃;
DOI:10.1021/jm300459a
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: N,N-Dimethylcarbamoyl chloride / toluene / 1.5 h / 80 °C
2.1: acetic acid; hydrogen bromide / 1 h / 35 °C
4.1: sodium nitrite
5.1: zinc; ethylene dibromide; chloro-trimethyl-silane / tetrahydrofuran / 1.5 h / 35 °C
5.2: 35 °C
With
chloro-trimethyl-silane; hydrogen bromide; acetic acid; ethylene dibromide; N,N-Dimethylcarbamoyl chloride; zinc; sodium nitrite;
In
tetrahydrofuran; toluene;
3.1: |Suzuki Coupling / 5.1: |Negishi Coupling / 5.2: |Negishi Coupling;
DOI:10.1021/jm300459a
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: dihydrogen peroxide; acetic acid / 2 h / 100 °C
2.1: N,N-Dimethylcarbamoyl chloride / toluene / 1.5 h / 80 °C
3.1: acetic acid; hydrogen bromide / 1 h / 35 °C
5.1: sodium nitrite
6.1: zinc; ethylene dibromide; chloro-trimethyl-silane / tetrahydrofuran / 1.5 h / 35 °C
6.2: 35 °C
With
chloro-trimethyl-silane; hydrogen bromide; dihydrogen peroxide; acetic acid; ethylene dibromide; N,N-Dimethylcarbamoyl chloride; zinc; sodium nitrite;
In
tetrahydrofuran; toluene;
4.1: |Suzuki Coupling / 6.1: |Negishi Coupling / 6.2: |Negishi Coupling;
DOI:10.1021/jm300459a
