7α-benzoylamino-3-(1-methyl-1H-tetrazol-5-yl)thiomethyl-1-oxa-3-cephem-4-carboxylic acid

Base Information

Chemical Name:7α-benzoylamino-3-(1-methyl-1H-tetrazol-5-yl)thiomethyl-1-oxa-3-cephem-4-carboxylic acid
CAS No.:70244-29-0
Molecular Formula:C₁₇H₁₆N₆O₅S
Molecular Weight:416.417
Hs Code.:

Synonyms:

Suppliers and Price of 7α-benzoylamino-3-(1-methyl-1H-tetrazol-5-yl)thiomethyl-1-oxa-3-cephem-4-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 7α-benzoylamino-3-(1-methyl-1H-tetrazol-5-yl)thiomethyl-1-oxa-3-cephem-4-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 7α-benzoylamino-3-(1-methyl-1H-tetrazol-5-yl)thiomethyl-1-oxa-3-cephem-4-carboxylic acid

There total 8 articles about 7α-benzoylamino-3-(1-methyl-1H-tetrazol-5-yl)thiomethyl-1-oxa-3-cephem-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67977-91-7,82768-86-3,94480-96-3
diphenylmethyl 7α-benzoylamino-3-methylene-1-oxacepham-4α-carboxylate

: 70244-29-0,83291-13-8
7α-benzoylamino-3-(1-methyl-1H-tetrazol-5-yl)thiomethyl-1-oxa-3-cephem-4-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1) Cl₂ / 1) CCl₄, 20 min, 0 deg C, 2) CH₂Cl₂-EtOAc, 1-2 h, RT

2: 98 percent / acetone; methanol / 2 h / Heating

3: 1) 0.1N NaOH aq., 2) 1 N HCl aq. / 1) acetone, -20 -> -10 deg C, 20 min

4: 1.) NaHCO₃, 30percent H₂O₂ aq, 2.) Na₂S₂O₃, HCl aq. / Na₂WO₄*2H₂O / 1.) acetone, water, 1 h, 0 deg C

With hydrogenchloride; sodium hydroxide; dihydrogen peroxide; chlorine; sodium hydrogencarbonate; sodium thiosulfate; sodium tungstate; In methanol; acetone;
DOI:10.1016/S0040-4020(01)92145-3

Reference yield:

: 83262-30-0
diphenylmethyl 7α-benzoylamino-3β-phenylseleno-3α-chloromethyl-1-oxacepham-4α-carboxylate

: 70244-29-0,83291-13-8
7α-benzoylamino-3-(1-methyl-1H-tetrazol-5-yl)thiomethyl-1-oxa-3-cephem-4-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / NaSMTZ

2: 1) Cl₂ / 1) CCl₄, 20 min, 0 deg C, 2) CH₂Cl₂-EtOAc, 1-2 h, RT

3: 98 percent / acetone; methanol / 2 h / Heating

4: 1) 0.1N NaOH aq., 2) 1 N HCl aq. / 1) acetone, -20 -> -10 deg C, 20 min

5: 1.) NaHCO₃, 30percent H₂O₂ aq, 2.) Na₂S₂O₃, HCl aq. / Na₂WO₄*2H₂O / 1.) acetone, water, 1 h, 0 deg C

With hydrogenchloride; sodium hydroxide; dihydrogen peroxide; chlorine; sodium hydrogencarbonate; sodium thiosulfate; sodium tungstate; In methanol; acetone;
DOI:10.1016/S0040-4020(01)92145-3

Reference yield:

: 88010-29-1
3-methylene-1-oxacepham methyl ester

: 70244-29-0,83291-13-8
7α-benzoylamino-3-(1-methyl-1H-tetrazol-5-yl)thiomethyl-1-oxa-3-cephem-4-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) α-picoline, 2.) HCl / 1.) CH2Cl2, CCl4, 0 deg C, 2 d, 2.) ether, CH2Cl2, 0 deg C, overnight

2: 83 percent / acetone; methanol / 6 h / Ambient temperature

3: 1) 0.1 N NaOH aq., 2) 1 N HCl aq. / 1) -7 -> -5 deg C, acetone, 30 min,

4: 1.) NaHCO₃, 30percent H₂O₂ aq, 2.) Na₂S₂O₃, HCl aq. / Na₂WO₄*2H₂O / 1.) acetone, water, 1 h, 0 deg C

With α-picoline; hydrogenchloride; sodium hydroxide; dihydrogen peroxide; sodium hydrogencarbonate; sodium thiosulfate; sodium tungstate; In methanol; acetone;
DOI:10.1016/S0040-4020(01)92145-3