6-(4-isopropylphenyl)-2H-spiro[benzofuran-3,1'-cyclohexan]-2-one

Base Information

Chemical Name:6-(4-isopropylphenyl)-2H-spiro[benzofuran-3,1'-cyclohexan]-2-one
CAS No.:1419174-48-3
Molecular Formula:C₂₂H₂₄O₂
Molecular Weight:320.431
Hs Code.:

Synonyms:

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Chemical Property of 6-(4-isopropylphenyl)-2H-spiro[benzofuran-3,1'-cyclohexan]-2-one

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Technology Process of 6-(4-isopropylphenyl)-2H-spiro[benzofuran-3,1'-cyclohexan]-2-one

There total 4 articles about 6-(4-isopropylphenyl)-2H-spiro[benzofuran-3,1'-cyclohexan]-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1419174-74-5
C₂₂H₂₅N

: 1419174-48-3
6-(4-isopropylphenyl)-2H-spiro[benzofuran-3,1'-cyclohexan]-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / ethylene glycol / 4 h / Reflux; Inert atmosphere

2: cesium acetate; palladium diacetate; [bis(acetoxy)iodo]benzene; silver(I) acetate; sodium acetate / chlorobenzene; tert-butyl alcohol / 12 h / 100 °C / Inert atmosphere

With [bis(acetoxy)iodo]benzene; silver(I) acetate; cesium acetate; sodium acetate; palladium diacetate; potassium hydroxide; In ethylene glycol; chlorobenzene; tert-butyl alcohol;
DOI:10.1021/ol303569b

Reference yield:

: 626603-27-8
1-(4-bromophenyl)cyclohexane-1-carbonitrile

: 1419174-48-3
6-(4-isopropylphenyl)-2H-spiro[benzofuran-3,1'-cyclohexan]-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: palladium dichloride; potassium carbonate / ethanol / 0.5 h / 20 °C / Inert atmosphere

2: potassium hydroxide / ethylene glycol / 4 h / Reflux; Inert atmosphere

3: cesium acetate; palladium diacetate; [bis(acetoxy)iodo]benzene; silver(I) acetate; sodium acetate / chlorobenzene; tert-butyl alcohol / 12 h / 100 °C / Inert atmosphere

With [bis(acetoxy)iodo]benzene; silver(I) acetate; cesium acetate; sodium acetate; palladium diacetate; potassium carbonate; potassium hydroxide; palladium dichloride; In ethanol; ethylene glycol; chlorobenzene; tert-butyl alcohol; 1: |Suzuki Coupling;
DOI:10.1021/ol303569b

Reference yield:

: 16532-79-9
4-Bromophenylacetonitrile

: 1419174-48-3
6-(4-isopropylphenyl)-2H-spiro[benzofuran-3,1'-cyclohexan]-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / dimethyl sulfoxide / 1 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: palladium dichloride; potassium carbonate / ethanol / 0.5 h / 20 °C / Inert atmosphere

3.1: potassium hydroxide / ethylene glycol / 4 h / Reflux; Inert atmosphere

4.1: cesium acetate; palladium diacetate; [bis(acetoxy)iodo]benzene; silver(I) acetate; sodium acetate / chlorobenzene; tert-butyl alcohol / 12 h / 100 °C / Inert atmosphere

With [bis(acetoxy)iodo]benzene; silver(I) acetate; cesium acetate; sodium acetate; palladium diacetate; sodium hydride; potassium carbonate; potassium hydroxide; palladium dichloride; In ethanol; ethylene glycol; dimethyl sulfoxide; chlorobenzene; tert-butyl alcohol; 2.1: |Suzuki Coupling;
DOI:10.1021/ol303569b