C₆₃H₈₃N₅O₁₀S

Base Information

Chemical Name:C₆₃H₈₃N₅O₁₀S
CAS No.:1332757-71-7
Molecular Formula:C₆₃H₈₃N₅O₁₀S
Molecular Weight:1102.45
Hs Code.:

C<sub>63</sub>H<sub>83</sub>N<sub>5</sub>O<sub>10</sub>S

Synonyms:

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Chemical Property of C₆₃H₈₃N₅O₁₀S

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Technology Process of C₆₃H₈₃N₅O₁₀S

There total 19 articles about C₆₃H₈₃N₅O₁₀S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: (2S,3S)-2-[((S)-2-{[(S)-2-Amino-3-(4-methoxy-phenyl)-propionyl]-methyl-amino}-propionyl)-methyl-amino]-3-methyl-pentanoic acid allyl ester

: 1332757-70-6
C₃₉H₄₈N₂O₆S

: 1332757-71-7
C₆₃H₈₃N₅O₁₀S

Guidance literature:: With pentafluorophenyl diphenyl-phosphinate; N-ethyl-N,N-diisopropylamine; at 0 - 20 ℃;
DOI:10.1016/j.tetlet.2011.05.107

Reference yield:

: 874674-84-7
(S)-N-methoxy-N-methyl-5-(tert-butyldimethylsilanyloxy)-3-methylpentanoic amide

: 1332757-71-7
C₆₃H₈₃N₅O₁₀S

Guidance literature:: Multi-step reaction with 13 steps

1: diethyl ether / 0.08 h / -10 °C

2: dimethylsulfide borane complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / toluene / 6 h / 40 °C

3: 2,6-dimethylpyridine / dichloromethane / 3 h / 0 - 20 °C

4: methanol; toluene-4-sulfonic acid / 2 h / 20 °C

5: oxalyl dichloride; dimethyl sulfoxide / 0.5 h / -78 °C

6: toluene / 4 h / 20 °C

7: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 3 h / 20 °C

8: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0 - 20 °C

9: hydrogenchloride / ethyl acetate / 3 h / 0 °C

10: dmap; 2,4,6-trichlorobenzoyl chloride; N-ethyl-N,N-diisopropylamine / 0 - 20 °C

11: trifluoromethylsulfonic anhydride; Triphenylphosphine oxide / dichloromethane / 0.5 h / 0 °C

12: tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-methylaniline / 2 h / 20 °C

13: pentafluorophenyl diphenyl-phosphinate; N-ethyl-N,N-diisopropylamine / 0 - 20 °C

With 2,6-dimethylpyridine; hydrogenchloride; methanol; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; lithium hydroxide monohydrate; trifluoromethylsulfonic anhydride; dimethylsulfide borane complex; 2,4,6-trichlorobenzoyl chloride; pentafluorophenyl diphenyl-phosphinate; toluene-4-sulfonic acid; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; HATU; N-methylaniline; Triphenylphosphine oxide; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene; 5: Swern oxidation / 6: Wittig reaction / 10: Yamaguchi esterification;
DOI:10.1016/j.tetlet.2011.05.107

Reference yield:

: (S)-4-benzyl-3-[(S)-4-(tert-butyldimethylsilanyloxy)-2-methylbutanoyl]oxazolidin-2-one

: 1332757-71-7
C₆₃H₈₃N₅O₁₀S

Guidance literature:: Multi-step reaction with 19 steps

1: lithium borohydride / tetrahydrofuran; methanol / 4 h / 0 °C

2: triethylamine / dichloromethane / 0.5 h / 20 °C

3: dimethyl sulfoxide / 4 h / 60 °C

4: diisobutylaluminium hydride / dichloromethane / 2 h / -78 °C

5: sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene; sodium formate / water; tert-butyl alcohol / 2 h / 0 °C

6: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 5 h / 0 - 20 °C

7: diethyl ether / 0.08 h / -10 °C

8: dimethylsulfide borane complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / toluene / 6 h / 40 °C

9: 2,6-dimethylpyridine / dichloromethane / 3 h / 0 - 20 °C

10: methanol; toluene-4-sulfonic acid / 2 h / 20 °C

11: oxalyl dichloride; dimethyl sulfoxide / 0.5 h / -78 °C

12: toluene / 4 h / 20 °C

13: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 3 h / 20 °C

14: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0 - 20 °C

15: hydrogenchloride / ethyl acetate / 3 h / 0 °C

16: dmap; 2,4,6-trichlorobenzoyl chloride; N-ethyl-N,N-diisopropylamine / 0 - 20 °C

17: trifluoromethylsulfonic anhydride; Triphenylphosphine oxide / dichloromethane / 0.5 h / 0 °C

18: tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-methylaniline / 2 h / 20 °C

19: pentafluorophenyl diphenyl-phosphinate; N-ethyl-N,N-diisopropylamine / 0 - 20 °C

With 2,6-dimethylpyridine; hydrogenchloride; methanol; dmap; lithium borohydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene; oxalyl dichloride; lithium hydroxide monohydrate; trifluoromethylsulfonic anhydride; dimethylsulfide borane complex; 2,4,6-trichlorobenzoyl chloride; pentafluorophenyl diphenyl-phosphinate; sodium formate; diisobutylaluminium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; N-methylaniline; Triphenylphosphine oxide; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene; tert-butyl alcohol; 11: Swern oxidation / 12: Wittig reaction / 16: Yamaguchi esterification;
DOI:10.1016/j.tetlet.2011.05.107