Nrf1-activator-1

Base Information

• Chemical Name: Nrf1-activator-1
• CAS No.: 1474034-05-3
• Molecular Formula: C₃₃H₄₄F₂N₂O₃
• Molecular Weight: 554.721
• Mol file: 1474034-05-3.mol

Synonyms:

Chemical Property of Nrf1-activator-1

Chemical Property:

• Boiling Point: 662.0±55.0 °C(Predicted)
• PKA: 13.71±0.70(Predicted)
• Density: 1.19±0.1 g/cm3(Predicted)
• Solubility.: ≥55.5 mg/mL in DMSO; insoluble in H2O; ≥25.05 mg/mL in EtOH

Purity/Quality:

97% ^*data from raw suppliers

RTA408 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Synthetic triterpenoids, such as RTA 408, are antioxidant inflammation modulator (AIM) that can inhibit tumor cell growth and metastasis via oncogenic signaling pathways. RTA 408 is an anticancer, anti-inflammatory, and antioxidant agent that protects human retinal pigment epithelial cells against H2O2-induced cell injury by activating NF-E2-related factor 2.

Technology Process of Nrf1-activator-1

There total 5 articles about Nrf1-activator-1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2-difluoropropanoic acid (373-96-6) + (4aR,6aS,6bR,8aS,12aS,12bR,14bS)-8a-amino-4,4,6a,6b,11,11,14b-heptamethyl-3,13-dioxo-3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-2-carbonitrile (1192123-13-9) → omaveloxolone (1474034-05-3)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃;

Reference yield:

2,2-difluoropropanoic acid (373-96-6) + C30H42N2O2 → RTA-408 (1474034-05-3)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃;

Reference yield:

bardoxolone (218600-44-3) → omaveloxolone (1474034-05-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: diphenyl phosphoryl azide; triethylamine / toluene / 0 - 20 °C

1.2: 2 h / 80 °C

2.1: water; hydrogenchloride / acetonitrile / 1.01 h / 0 - 20 °C

3.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 20 °C

With hydrogenchloride; dmap; diphenyl phosphoryl azide; water; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; toluene; acetonitrile;

upstream raw materials:

bardoxolone

2,2-difluoropropanoic acid

(4aR,6aS,6bR,8aS,12aS,12bR,14bS)-8a-amino-4,4,6a,6b,11,11,14b-heptamethyl-3,13-dioxo-3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-2-carbonitrile