methyl (6-chloro-7-hydroxy-2-oxo-2H-chromen-4-yl)acetate

Base Information

Chemical Name:methyl (6-chloro-7-hydroxy-2-oxo-2H-chromen-4-yl)acetate
CAS No.:72304-22-4
Molecular Formula:C₁₂H₉ClO₅
Molecular Weight:268.653
Hs Code.:
DSSTox Substance ID:DTXSID601197866
Mol file:72304-22-4.mol

Synonyms:72304-22-4;methyl (6-chloro-7-hydroxy-2-oxo-2H-chromen-4-yl)acetate;Methyl 2-(6-chloro-7-hydroxy-2-oxo-2H-chromen-4-yl)acetate;methyl 2-(6-chloro-7-hydroxy-2-oxochromen-4-yl)acetate;MFCD11108908;Methyl (6-chloro-7-hydroxy-2-oxo-2H-chromen-4-yl)-acetate;DTXSID601197866;AKOS005175212;NS-04289;CS-0302076;EN300-302516;Methyl 6-chloro-7-hydroxy-2-oxo-2H-1-benzopyran-4-acetate;Methyl2-(6-chloro-7-hydroxy-2-oxo-2H-chromen-4-yl)acetate

Suppliers and Price of methyl (6-chloro-7-hydroxy-2-oxo-2H-chromen-4-yl)acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Methyl2-(6-chloro-7-hydroxy-2-oxo-2H-chromen-4-yl)acetate 97%
5g
$ 527.00

Chemenu
Methyl2-(6-chloro-7-hydroxy-2-oxo-2H-chromen-4-yl)acetate 97%
5g
$ 497.00

Total 3 raw suppliers

Chemical Property of methyl (6-chloro-7-hydroxy-2-oxo-2H-chromen-4-yl)acetate

Chemical Property:

Melting Point:240 °C(Solv: methanol (67-56-1))
Boiling Point:451.1±45.0 °C(Predicted)
PKA:6.24±0.20(Predicted)
Density:1.467±0.06 g/cm3(Predicted)
XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:268.0138511
Heavy Atom Count:18
Complexity:392

Purity/Quality:

98%min ^*data from raw suppliers

Methyl2-(6-chloro-7-hydroxy-2-oxo-2H-chromen-4-yl)acetate 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC(=O)CC1=CC(=O)OC2=CC(=C(C=C12)Cl)O

Technology Process of methyl (6-chloro-7-hydroxy-2-oxo-2H-chromen-4-yl)acetate

There total 2 articles about methyl (6-chloro-7-hydroxy-2-oxo-2H-chromen-4-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1830-54-2
3-oxopentanedioic acid dimethyl ester

: 95-88-5
4-Chlororesorcinol

: 72304-22-4
methyl 2-(6-chloro-7-hydroxy-2-oxo-2H-chromen-4-yl)acetate

: C₁₇H₁₀Cl₂O₆

Guidance literature:: With methanesulfonic acid; at 0 - 20 ℃; for 120.984h;
DOI:10.1016/j.dyepig.2011.05.008

Reference yield:

: 72304-22-4
methyl 2-(6-chloro-7-hydroxy-2-oxo-2H-chromen-4-yl)acetate

Guidance literature:: Aus entspr. Cumarin (V) nach Fischer;

Reference yield:

: 72304-22-4
methyl 2-(6-chloro-7-hydroxy-2-oxo-2H-chromen-4-yl)acetate

: 1332343-93-7
C₁₉H₁₆ClNO₄

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,2-dimethoxyethane / 70 - 75 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,2-dimethoxyethane; acetonitrile;
DOI:10.1016/j.dyepig.2011.05.008