BrH*C₁₅H₁₀N₂O

Base Information

• Chemical Name: BrH*C₁₅H₁₀N₂O
• CAS No.: 1380072-29-6
• Molecular Formula: BrH*C₁₅H₁₀N₂O
• Molecular Weight: 315.169
• Mol file: 1380072-29-6.mol

Synonyms:

Chemical Property of BrH*C₁₅H₁₀N₂O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of BrH*C₁₅H₁₀N₂O

There total 3 articles about BrH*C₁₅H₁₀N₂O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-hydroxymethyl-2-(3-cyanophenylethynyl)pyridine (1380072-27-4) → BrH*C15H10N2O (1380072-29-6)

Guidance literature:

With hydrogen bromide; In methanol;

DOI:10.1021/ml3000726

Reference yield:

3-cyanobromobenzene (6952-59-6) → BrH*C15H10N2O (1380072-29-6)

Guidance literature:

Multi-step reaction with 3 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 20 °C / Inert atmosphere

2: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; triethylamine / tetrahydrofuran; N,N-dimethyl-formamide / 70 °C / Inert atmosphere

3: hydrogen bromide / methanol

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; hydrogen bromide; triethylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 2: Sonogashira coupling;

DOI:10.1021/ml3000726

Reference yield:

3-((trimethylsilyl)ethynyl)benzonitrile (190771-22-3) → BrH*C15H10N2O (1380072-29-6)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; triethylamine / tetrahydrofuran; N,N-dimethyl-formamide / 70 °C / Inert atmosphere

2: hydrogen bromide / methanol

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; hydrogen bromide; triethylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 1: Sonogashira coupling;

DOI:10.1021/ml3000726

upstream raw materials:

6-hydroxymethyl-2-(3-cyanophenylethynyl)pyridine

3-cyanobromobenzene

3-((trimethylsilyl)ethynyl)benzonitrile

Refernces