Technology Process of (R)-methyl 3-((3aR,5R,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]-dioxol-5-yl)-3-((S)-2-methoxy-2-phenylacetamido)propanoate
There total 8 articles about (R)-methyl 3-((3aR,5R,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]-dioxol-5-yl)-3-((S)-2-methoxy-2-phenylacetamido)propanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(S)-2-methoxy-2-phenylacetic acid;
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
dichloromethane;
at 0 ℃;
for 0.25h;
Inert atmosphere;
C2HF3O2*C12H21NO6;
With
N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 0 - 20 ℃;
for 8h;
Inert atmosphere;
DOI:10.1021/jo300865d
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 20 °C
2.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C
3.1: dichloromethane / 2 h / 0 °C / Inert atmosphere
4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.25 h / 0 °C / Inert atmosphere
4.2: 8 h / 0 - 20 °C / Inert atmosphere
With
palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
methanol; dichloromethane;
DOI:10.1021/jo300865d
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: potassium hydroxide / 1,4-dioxane / 1 h / Reflux
1.2: 12 h / 0 - 20 °C
2.1: water; acetic acid / 12 h / 20 °C
3.1: sodium periodate / dichloromethane / 6 h / 0 - 20 °C
4.1: dichloromethane / 4 h / 0 - 20 °C
5.1: 12 h / 20 °C
6.1: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 20 °C
7.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C
8.1: dichloromethane / 2 h / 0 °C / Inert atmosphere
9.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.25 h / 0 °C / Inert atmosphere
9.2: 8 h / 0 - 20 °C / Inert atmosphere
With
sodium periodate; palladium 10% on activated carbon; water; hydrogen; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium hydroxide;
In
1,4-dioxane; methanol; dichloromethane;
4.1: Wittig reaction / 5.1: Aza-Michael addition;
DOI:10.1021/jo300865d
