trisodium salt of (6R,7R)-7-<2-(2-amino-4-thiazolyl)-2-<(Z)-<(S)-carboxy(3,4-dihydroxyphenyl)methyl>oxyimino>acetamido>-3-<(2-carboxy-5-methyl<1,2,4>triazolo<1,5-a>pyrimidin-7-yl)thiomethyl>-8-oxo-5-thia-1-azabicyclo<4,2,0>oct-2-ene-2-carboxylic acid

Base Information

• Chemical Name: trisodium salt of (6R,7R)-7-<2-(2-amino-4-thiazolyl)-2-<(Z)-<(S)-carboxy(3,4-dihydroxyphenyl)methyl>oxyimino>acetamido>-3-<(2-carboxy-5-methyl<1,2,4>triazolo<1,5-a>pyrimidin-7-yl)thiomethyl>-8-oxo-5-thia-1-azabicyclo<4,2,0>oct-2-ene-2-carboxylic acid
• CAS No.: 106819-87-8
• Molecular Formula: C₂₈H₂₀N₉O₁₁S₃*3Na
• Molecular Weight: 823.688

Synonyms:

Chemical Property of trisodium salt of (6R,7R)-7-<2-(2-amino-4-thiazolyl)-2-<(Z)-<(S)-carboxy(3,4-dihydroxyphenyl)methyl>oxyimino>acetamido>-3-<(2-carboxy-5-methyl<1,2,4>triazolo<1,5-a>pyrimidin-7-yl)thiomethyl>-8-oxo-5-thia-1-azabicyclo<4,2,0>oct-2-ene-2-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of trisodium salt of (6R,7R)-7-<2-(2-amino-4-thiazolyl)-2-<(Z)-<(S)-carboxy(3,4-dihydroxyphenyl)methyl>oxyimino>acetamido>-3-<(2-carboxy-5-methyl<1,2,4>triazolo<1,5-a>pyrimidin-7-yl)thiomethyl>-8-oxo-5-thia-1-azabicyclo<4,2,0>oct-2-ene-2-carboxylic acid

There total 7 articles about trisodium salt of (6R,7R)-7-<2-(2-amino-4-thiazolyl)-2-<(Z)-<(S)-carboxy(3,4-dihydroxyphenyl)methyl>oxyimino>acetamido>-3-<(2-carboxy-5-methyl<1,2,4>triazolo<1,5-a>pyrimidin-7-yl)thiomethyl>-8-oxo-5-thia-1-azabicyclo<4,2,0>oct-2-ene-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-oxo-2-(2-aminothiazol-4-yl)acetic acid (73150-67-1) → trisodium salt of (6R,7R)-7-<2-(2-amino-4-thiazolyl)-2-<(Z)-<(S)-carboxy(3,4-dihydroxyphenyl)methyl>oxyimino>acetamido>-3-<(2-carboxy-5-methyl<1,2,4>triazolo<1,5-a>pyrimidin-7-yl)thiomethyl>-8-oxo-5-thia-1-azabicyclo<4,2,0>oct-2-ene-2-carboxylic acid (106819-87-8,106819-88-9,106861-48-7,120633-41-2,146727-60-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 82 percent / methanol / 2 h / Ambient temperature

2: 39 percent / DCC / tetrahydrofuran; CH₂Cl₂ / 1.) 1 h, 0 deg C, 2.) 21 h, RT

3: 1.) CF₃CO₂H 2.) aq. NaHCO₃ / 1.) anisole, 4h, RT

With sodium hydrogencarbonate; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1246/bcsj.63.3073

Reference yield:

t-butyl (S)-2-aminooxy-2-(3,4-O-isopropylidenedioxyphenyl)acetate (120633-39-8) → trisodium salt of (6R,7R)-7-<2-(2-amino-4-thiazolyl)-2-<(Z)-<(S)-carboxy(3,4-dihydroxyphenyl)methyl>oxyimino>acetamido>-3-<(2-carboxy-5-methyl<1,2,4>triazolo<1,5-a>pyrimidin-7-yl)thiomethyl>-8-oxo-5-thia-1-azabicyclo<4,2,0>oct-2-ene-2-carboxylic acid (106819-87-8,106819-88-9,106861-48-7,120633-41-2,146727-60-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 82 percent / methanol / 2 h / Ambient temperature

2: 39 percent / DCC / tetrahydrofuran; CH₂Cl₂ / 1.) 1 h, 0 deg C, 2.) 21 h, RT

3: 1.) CF₃CO₂H 2.) aq. NaHCO₃ / 1.) anisole, 4h, RT

With sodium hydrogencarbonate; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1246/bcsj.63.3073

Reference yield:

2-(2-amino-4-thiazolyl)-2-<(Z)-<(S)-t-butoxycarbonyl(3,4-O-isopropylidenedioxyphenyl)methyl>oxyimino>acetic acid (120633-40-1) → trisodium salt of (6R,7R)-7-<2-(2-amino-4-thiazolyl)-2-<(Z)-<(S)-carboxy(3,4-dihydroxyphenyl)methyl>oxyimino>acetamido>-3-<(2-carboxy-5-methyl<1,2,4>triazolo<1,5-a>pyrimidin-7-yl)thiomethyl>-8-oxo-5-thia-1-azabicyclo<4,2,0>oct-2-ene-2-carboxylic acid (106819-87-8,106819-88-9,106861-48-7,120633-41-2,146727-60-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 39 percent / DCC / tetrahydrofuran; CH₂Cl₂ / 1.) 1 h, 0 deg C, 2.) 21 h, RT

2: 1.) CF₃CO₂H 2.) aq. NaHCO₃ / 1.) anisole, 4h, RT

With sodium hydrogencarbonate; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1246/bcsj.63.3073

upstream raw materials:

diphenylmethyl (6R,7R)-7-<2-(2-amino-4-thiazolyl)-2-<(Z)-<(S)-t-butoxycarbonyl(3,4-isopropylidenedioxyphenyl)methyl>oxyimino>acetamido>-3-<<<2-(diphenylmethyl)oxycarbonyl>-5-methyl<1,2,4>triazolo<1,5-a>pyrimidin-7-yl>thiomethyl>-8-oxo-5-thia-1-azabicycl

2-oxo-2-(2-aminothiazol-4-yl)acetic acid

t-butyl (S)-2-aminooxy-2-(3,4-O-isopropylidenedioxyphenyl)acetate

2-(2-amino-4-thiazolyl)-2-<(Z)-<(S)-t-butoxycarbonyl(3,4-O-isopropylidenedioxyphenyl)methyl>oxyimino>acetic acid

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