2'-[4-(tert-butoxycarbonylamino-methyl)-phenylcarbamoyl]-4-isobutylcarbamoyl-biphenyl-2-carboxylic acid methyl ester

Base Information

Chemical Name:2'-[4-(tert-butoxycarbonylamino-methyl)-phenylcarbamoyl]-4-isobutylcarbamoyl-biphenyl-2-carboxylic acid methyl ester
CAS No.:790230-03-4
Molecular Formula:C₃₂H₃₇N₃O₆
Molecular Weight:559.662
Hs Code.:

2'-[4-(<i>tert</i>-butoxycarbonylamino-methyl)-phenylcarbamoyl]-4-isobutylcarbamoyl-biphenyl-2-carboxylic acid methyl ester

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Chemical Property of 2'-[4-(tert-butoxycarbonylamino-methyl)-phenylcarbamoyl]-4-isobutylcarbamoyl-biphenyl-2-carboxylic acid methyl ester

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Technology Process of 2'-[4-(tert-butoxycarbonylamino-methyl)-phenylcarbamoyl]-4-isobutylcarbamoyl-biphenyl-2-carboxylic acid methyl ester

There total 7 articles about 2'-[4-(tert-butoxycarbonylamino-methyl)-phenylcarbamoyl]-4-isobutylcarbamoyl-biphenyl-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5-chlorocarbonyl-2-trifluoromethanesulfonyloxy-benzoic acid methyl ester

: 790230-03-4
2'-[4-(tert-butoxycarbonylamino-methyl)-phenylcarbamoyl]-4-isobutylcarbamoyl-biphenyl-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 4.09 g / triethylamine / CH₂Cl₂ / 1 h / 0 °C

2: 93 percent / K₃PO₄ / Pd(PPh₃)4 / dimethylformamide / 5 h / 100 °C

3: 100 percent / NaH₂PO₄*2H₂O; 2-methyl-2-butene; sodium chlorite / 2-methyl-propan-2-ol; H₂O; acetonitrile / 6 h / 20 °C

4: 350 mg / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 1-hydroxybenzotriazole / dimethylformamide / 12 h / 50 °C

With sodium chlorite; potassium phosphate; sodium dihydrogenphosphate; 2-methyl-but-2-ene; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol; 2: Suzuki coupling;
DOI:10.1016/j.bmc.2006.08.010

Reference yield:

: 41489-76-3
methyl-5-formyl-2-hydroxybenzoate

: 790230-03-4
2'-[4-(tert-butoxycarbonylamino-methyl)-phenylcarbamoyl]-4-isobutylcarbamoyl-biphenyl-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 48 percent / pyridine / CH₂Cl₂ / 0.5 h / 20 °C

2: 6.83 g / NaH₂PO₄*H₂O; 2-methyl-2-butene; sodium chlorite / 2-methyl-propan-2-ol; H₂O; acetonitrile / 1 h / 20 °C

3: oxalyl chloride / CH₂Cl₂; dimethylformamide / 2 h / 20 °C

4: 4.09 g / triethylamine / CH₂Cl₂ / 1 h / 0 °C

5: 93 percent / K₃PO₄ / Pd(PPh₃)4 / dimethylformamide / 5 h / 100 °C

6: 100 percent / NaH₂PO₄*2H₂O; 2-methyl-2-butene; sodium chlorite / 2-methyl-propan-2-ol; H₂O; acetonitrile / 6 h / 20 °C

7: 350 mg / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 1-hydroxybenzotriazole / dimethylformamide / 12 h / 50 °C

With pyridine; sodium chlorite; potassium phosphate; sodium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol; 5: Suzuki coupling;
DOI:10.1016/j.bmc.2006.08.010

Reference yield:

: 173251-53-1
methyl 5-formyl-2-{[(trifluoromethyl)sulfonyl]oxy}benzoate

: 790230-03-4
2'-[4-(tert-butoxycarbonylamino-methyl)-phenylcarbamoyl]-4-isobutylcarbamoyl-biphenyl-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 6.83 g / NaH₂PO₄*H₂O; 2-methyl-2-butene; sodium chlorite / 2-methyl-propan-2-ol; H₂O; acetonitrile / 1 h / 20 °C

2: oxalyl chloride / CH₂Cl₂; dimethylformamide / 2 h / 20 °C

3: 4.09 g / triethylamine / CH₂Cl₂ / 1 h / 0 °C

4: 93 percent / K₃PO₄ / Pd(PPh₃)4 / dimethylformamide / 5 h / 100 °C

5: 100 percent / NaH₂PO₄*2H₂O; 2-methyl-2-butene; sodium chlorite / 2-methyl-propan-2-ol; H₂O; acetonitrile / 6 h / 20 °C

6: 350 mg / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 1-hydroxybenzotriazole / dimethylformamide / 12 h / 50 °C

With sodium chlorite; potassium phosphate; sodium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol; 4: Suzuki coupling;
DOI:10.1016/j.bmc.2006.08.010