Technology Process of (5S,6R)-5-Benzyloxy-6-pentyl-5,6-dihydro-pyran-2-one
There total 7 articles about (5S,6R)-5-Benzyloxy-6-pentyl-5,6-dihydro-pyran-2-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
4 A molecular sieve; sodium acetate; pyridinium chlorochromate;
In
dichloromethane;
for 1h;
Ambient temperature;
DOI:10.1021/jo00270a015
- Guidance literature:
-
Multi-step reaction with 7 steps
2: tert-butyl hydroperoxide (TBHP), VO(acac)2 / CH2Cl2 / 14 h / 0 °C
3: imidazole / dimethylformamide / 1 h / 0 °C
4: LiAlH4 / diethyl ether / 0.5 h / -60 °C
5: oil-free NaH / tetrahydrofuran; dimethylformamide / 0.5 h / Ambient temperature
6: n-Bu4NF / tetrahydrofuran / 0.17 h / 0 °C
7: pyridinium chlorochromate (PCC), sodium acetate, 4A molecular sieves / CH2Cl2 / 1 h / Ambient temperature
With
1H-imidazole; tert.-butylhydroperoxide; lithium aluminium tetrahydride; bis(acetylacetonate)oxovanadium; 4 A molecular sieve; tetrabutyl ammonium fluoride; sodium acetate; sodium hydride; pyridinium chlorochromate;
In
tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00270a015
- Guidance literature:
-
Multi-step reaction with 6 steps
1: tert-butyl hydroperoxide (TBHP), VO(acac)2 / CH2Cl2 / 14 h / 0 °C
2: imidazole / dimethylformamide / 1 h / 0 °C
3: LiAlH4 / diethyl ether / 0.5 h / -60 °C
4: oil-free NaH / tetrahydrofuran; dimethylformamide / 0.5 h / Ambient temperature
5: n-Bu4NF / tetrahydrofuran / 0.17 h / 0 °C
6: pyridinium chlorochromate (PCC), sodium acetate, 4A molecular sieves / CH2Cl2 / 1 h / Ambient temperature
With
1H-imidazole; tert.-butylhydroperoxide; lithium aluminium tetrahydride; bis(acetylacetonate)oxovanadium; 4 A molecular sieve; tetrabutyl ammonium fluoride; sodium acetate; sodium hydride; pyridinium chlorochromate;
In
tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00270a015