Butanoic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-, (R)-

Base Information

Chemical Name:Butanoic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-, (R)-
CAS No.:139561-10-7
Molecular Formula:C10H19NO4
Molecular Weight:217.26200
Hs Code.:
Mol file:139561-10-7.mol

Synonyms:(R)-4-tert-Butoxycarbonylamino-2-methyl-butyric acid;(R)-4-[(tert-butoxycarbonyl)amino]-2-methylbutanoic acid;[2R]-4-[(tert-butoxycarbonyl)amino]-2-methylbutanoic acid;

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Butanoic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-, (R)-

Chemical Property:

PSA：75.63000
LogP:2.01280

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Butanoic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-, (R)-

There total 9 articles about Butanoic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 139462-30-9
<4S,3(2R)>-4-benzyl-3-<4-((tert-butoxycarbonyl)amino)-2-methylbutanoyl>-2-oxazolidinone

: 139561-10-7,205808-16-8
<2R>-4-((tert-butoxycarbonyl)amino)-2-methylbutanoic acid

Guidance literature:: With lithium hydroxide; dihydrogen peroxide; In tetrahydrofuran; water; at 0 ℃; for 0.5h;
DOI:10.1021/ja00050a024

Reference yield: 86.0%

: 259857-49-3
tert-butyl (3R)-3-methyl-2-oxopyrrolidine-1-carboxylate

: 139561-10-7,205808-16-8
<2R>-4-((tert-butoxycarbonyl)amino)-2-methylbutanoic acid

: 205808-16-8
(S)-4-[(tert-butoxycarbonyl)amino]-2-methylbutanoic acid

Guidance literature:: With lithium hydroxide; water; In tetrahydrofuran; for 2h;
DOI:10.1002/(SICI)1522-2675(19991215)82:12<2365::AID-HLCA2365>3.0.CO;2-#

Reference yield:

: 139462-29-6
(R)-5-((S)-4-benzyl-2-oxooxazolidin-3-yl)-4-methyl-5-oxopentanoic acid

: 139561-10-7,205808-16-8
<2R>-4-((tert-butoxycarbonyl)amino)-2-methylbutanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 71 percent / Et₃N, diphenylphosphoryl azide / 15 h / Heating

2: 96 percent / 30percent aq. H₂O₂, LiOH / tetrahydrofuran; H₂O / 0.5 h / 0 °C

With lithium hydroxide; diphenylphosphoranyl azide; dihydrogen peroxide; triethylamine; In tetrahydrofuran; water;
DOI:10.1021/ja00050a024